| The effect of progesterone on coronary blood flow in anaesthesized pigs. | |
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MedLine Citation:
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PMID: 11434325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was designed to investigate the effect of progesterone on the coronary circulation and to determine the mechanisms involved. In pigs anaesthetized with sodium pentobarbitone, changes in left circumflex or anterior descending coronary blood flow caused by intravenous infusion of progesterone at constant heart rate and arterial blood pressure were assessed using an electromagnetic flowmeter. In 14 pigs, infusion of 1 mg h(-1) of progesterone caused an increase in coronary blood flow without affecting left ventricular dP/dtmax (rate of change of left ventricular systolic pressure) and filling pressures of the heart. In a further four pigs, this vasodilatory coronary effect was enhanced by graded increases in the dose of the hormone of between 1, 2 and 3 mg h(-1). The mechanisms of the above response were studied in the 14 pigs by repeating the experiment after haemodynamic variables had returned to the control values observed before infusion. In six pigs, blockade of muscarinic cholinoceptors and adrenoceptors with atropine, propranolol and phentolamine did not affect the coronary vasodilatation caused by progesterone. In the remaining eight pigs, this response was abolished by intracoronary injection of N(omega)-nitro-L-arginine methyl ester (L-NAME) even when performed after reversing the increase in arterial blood pressure and coronary vascular resistance caused by L-NAME with continuous intravenous infusion of papaverine. The present study showed that intravenous infusion of progesterone primarily caused coronary vasodilatation. The mechanism of this response was shown to involve the endothelial release of nitric oxide. |
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Authors:
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C Molinari; A Battaglia; E Grossini; D A Mary; J B Stoker; N Surico; G Vacca |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental physiology Volume: 86 ISSN: 0958-0670 ISO Abbreviation: Exp. Physiol. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-07-02 Completed Date: 2001-08-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: England |
Other Details:
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Languages: eng Pagination: 101-8 Citation Subset: IM |
Affiliation:
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Laboratorio de Fisiologia, Dipartimento di Scienze Mediche, Facoltà di Medicina e Chirurgia di Novara, Università del Piemonte Orientale A. Avogadro, via Solaroli 17, I-28100 Novara, Italy. molinari@med.unipmn.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / drug effects* Enzyme Inhibitors / pharmacology Female NG-Nitroarginine Methyl Ester / pharmacology Progesterone / pharmacology* Receptors, Adrenergic / physiology Receptors, Muscarinic / physiology Swine Vasodilation |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Receptors, Adrenergic; 0/Receptors, Muscarinic; 50903-99-6/NG-Nitroarginine Methyl Ester; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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