| The effect of proadifen, a drug metabolism inhibitor, on action of imipramine and desipramine in mice. | |
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MedLine Citation:
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PMID: 7187047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Proadifen (SKF 524 A) inhibited the following effects of imipramine (IMI), without affecting those of desipramine (DMI) in mice: antagonism towards reserpine-induced hypothermia, ptosis and sedation, antagonism to apomorphine hypothermia and insignificant shortening of the immobility time in the behavioral despair test. Cerebral levels of DMI were very low after administration of IMI; pretreatment with proadifen did not affect the already low levels of DMI but significantly elevated these of IMI. This may indicate that some other than DMI metabolites (e.g., 2-hydroxy-derivatives) may be of importance for the action of IMI in mice in the tests employed in this study. |
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Authors:
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J Maj; M Melzacka; Z Rogóz; G Skuza; H Sowińska |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Polish journal of pharmacology and pharmacy Volume: 34 ISSN: 0301-0244 ISO Abbreviation: Pol J Pharmacol Pharm Publication Date: 1982 Nov-Dec |
Date Detail:
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Created Date: 1983-12-20 Completed Date: 1983-12-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0366561 Medline TA: Pol J Pharmacol Pharm Country: POLAND |
Other Details:
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Languages: eng Pagination: 323-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apomorphine / pharmacology Behavior, Animal / drug effects Blepharoptosis / chemically induced Body Temperature / drug effects Brain Chemistry / drug effects Desipramine / antagonists & inhibitors* Hypnotics and Sedatives Imipramine / antagonists & inhibitors* Male Mice Proadifen / pharmacology* Reserpine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 302-33-0/Proadifen; 50-47-5/Desipramine; 50-49-7/Imipramine; 50-55-5/Reserpine; 58-00-4/Apomorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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