Document Detail

The effect of prior bisphosphonate therapy on the subsequent therapeutic effects of strontium ranelate over 2 years.
MedLine Citation:
PMID:  21274515     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Many osteoporotic women commenced on strontium ranelate have already received treatment with bisphosphonates. This study investigates whether prior bisphosphonate use impairs the subsequent therapeutic response to strontium ranelate.
METHODS: Women were recruited who were either bisphosphonate naïve or currently receiving a bisphosphonate. All women received strontium ranelate and were followed up for 2 years.
RESULTS: One hundred and twenty women were recruited. After 2 years, the bisphosphonate-naïve group had significant BMD increases of 8.9%, 6.0% and 6.4% at the spine, hip and heel, respectively. In the prior bisphosphonate group, BMD increased significantly at the spine (4.0%) and hip (2.5%) but not at the heel. At all time points at all sites, the BMD increase was greater in the bisphosphonate-naïve group. BMD at the spine did not increase during the first 6 months in the prior bisphosphonate group but then increased in parallel with the bisphosphonate-naïve group. In contrast, the difference between the two groups in hip BMD continued to increase throughout the 2 years. P1NP was suppressed in the prior bisphosphonate group for the first 6 months.
CONCLUSIONS: After bisphosphonate exposure, the BMD response to strontium ranelate is blunted for only 6 months at the spine. At the hip, a degree of blunting was observed over 2 years, although there was an overall increase in hip BMD in contrast to the heel where no increase in BMD was observed.
E T Middleton; S A Steel; M Aye; S M Doherty
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-28
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  23     ISSN:  1433-2965     ISO Abbreviation:  Osteoporos Int     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-02     Completed Date:  2012-03-21     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  295-303     Citation Subset:  IM    
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MeSH Terms
Bone Density / drug effects
Bone Density Conservation Agents / pharmacology,  therapeutic use*
Diphosphonates / pharmacology,  therapeutic use*
Follow-Up Studies
Hip Joint / physiopathology
Middle Aged
Organometallic Compounds / pharmacology,  therapeutic use*
Osteoporosis, Postmenopausal / complications,  drug therapy*,  physiopathology
Osteoporotic Fractures / etiology,  prevention & control
Spine / physiopathology
Thiophenes / pharmacology,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Diphosphonates; 0/Organometallic Compounds; 0/Thiophenes; 04NQ160FRU/strontium ranelate
Comment In:
Orthopade. 2014 Feb;43(2):182

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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