| The effect of presynaptic catecholamine depletion on 6-hydroxymelatonin sulfate: a double blind study of alpha-methyl-para-tyrosine. | |
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MedLine Citation:
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PMID: 10082229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because it is a competitive inhibitor of tyrosine hydroxylase, alpha-methyl-para-tyrosine (AMPT) is used to study psychiatric disorders. Melatonin serves as a biological marker of catecholamine function since its secretion is regulated by noradrenergic neurons via beta-adrenergic receptors in the pineal gland. Ten healthy volunteers were administered AMPT in a double-blind placebo controlled study. When subjects received AMPT, nocturnal 6-hydroxymelatonin sulfate (6-SM) decreased significantly as compared with promethazine (night 1 P=0.002; and night 2 P=0.001). Urinary MHPG also decreased on both study days (DF1,9 F=9.82, GG=0.0121). Nocturnal 6-SM excretion and melatonin secretion correlated highly (r=0.91, P=0.0007). Behavioral ratings did not reveal a difference in symptomatology and did not correlate with changes in 6-SM or MHPG. This study demonstrates in healthy controls that 6-SM reliably reflects presynaptic catecholamine depletion induced by AMPT without the emergence of behavioral symptoms. |
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Authors:
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L E Krahn; S C Lin; G G Klee; P Y Lu; S J Ory; R C Zimmermann |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Volume: 9 ISSN: 0924-977X ISO Abbreviation: Eur Neuropsychopharmacol Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-05-26 Completed Date: 1999-05-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9111390 Medline TA: Eur Neuropsychopharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 61-6 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Psychology, Mayo Clinic and Foundation, Rochester, MN 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Area Under Curve Catecholamines / metabolism* Cross-Over Studies Double-Blind Method Enzyme Inhibitors / adverse effects, pharmacology* Female Humans Male Melatonin / analogs & derivatives*, blood, metabolism, urine Norepinephrine / metabolism Receptors, Presynaptic / metabolism* Tyrosine 3-Monooxygenase / antagonists & inhibitors* alpha-Methyltyrosine / adverse effects, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR585/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Enzyme Inhibitors; 0/Receptors, Presynaptic; 2208-41-5/6-hydroxymelatonin; 51-41-2/Norepinephrine; 658-48-0/alpha-Methyltyrosine; 73-31-4/Melatonin; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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