Document Detail

The effect of presynaptic catecholamine depletion on 6-hydroxymelatonin sulfate: a double blind study of alpha-methyl-para-tyrosine.
MedLine Citation:
PMID:  10082229     Owner:  NLM     Status:  MEDLINE    
Because it is a competitive inhibitor of tyrosine hydroxylase, alpha-methyl-para-tyrosine (AMPT) is used to study psychiatric disorders. Melatonin serves as a biological marker of catecholamine function since its secretion is regulated by noradrenergic neurons via beta-adrenergic receptors in the pineal gland. Ten healthy volunteers were administered AMPT in a double-blind placebo controlled study. When subjects received AMPT, nocturnal 6-hydroxymelatonin sulfate (6-SM) decreased significantly as compared with promethazine (night 1 P=0.002; and night 2 P=0.001). Urinary MHPG also decreased on both study days (DF1,9 F=9.82, GG=0.0121). Nocturnal 6-SM excretion and melatonin secretion correlated highly (r=0.91, P=0.0007). Behavioral ratings did not reveal a difference in symptomatology and did not correlate with changes in 6-SM or MHPG. This study demonstrates in healthy controls that 6-SM reliably reflects presynaptic catecholamine depletion induced by AMPT without the emergence of behavioral symptoms.
L E Krahn; S C Lin; G G Klee; P Y Lu; S J Ory; R C Zimmermann
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  9     ISSN:  0924-977X     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-05-26     Completed Date:  1999-05-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
Department of Psychiatry and Psychology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
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MeSH Terms
Area Under Curve
Catecholamines / metabolism*
Cross-Over Studies
Double-Blind Method
Enzyme Inhibitors / adverse effects,  pharmacology*
Melatonin / analogs & derivatives*,  blood,  metabolism,  urine
Norepinephrine / metabolism
Receptors, Presynaptic / metabolism*
Tyrosine 3-Monooxygenase / antagonists & inhibitors*
alpha-Methyltyrosine / adverse effects,  pharmacology*
Grant Support
Reg. No./Substance:
0/Catecholamines; 0/Enzyme Inhibitors; 0/Receptors, Presynaptic; 2208-41-5/6-hydroxymelatonin; 51-41-2/Norepinephrine; 658-48-0/alpha-Methyltyrosine; 73-31-4/Melatonin; EC 3-Monooxygenase

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