Document Detail

The effect of a preoperative erythropoietin protocol as part of a multifaceted blood management program in daily clinical practice.
MedLine Citation:
PMID:  23240859     Owner:  NLM     Status:  Publisher    
BACKGROUND: The effectiveness of a preoperative erythropoietin (EPO) protocol to reduce allogeneic blood transfusions (ABTs) in daily clinical practice has been insufficiently studied. This study evaluated the effect of such a protocol, as part of a multifaceted blood management program, in patients undergoing total hip arthroplasty (THA). STUDY DESIGN AND METHODS: This retrospective observational study was designed as an interrupted time series (1999-2010). The intervention was the introduction of an EPO protocol in THA patients in 2003. Patients were classified according to preoperative hemoglobin (Hb) level: 10 to 13 g/dL (eligible patients for EPO) and more than 13 g/dL. The primary outcome was the percentage of patients receiving an ABT. Segmented regression analysis was used to estimate changes in outcome after the intervention. RESULTS: A total of 4568 THA patients were included. The absolute reductions in ABTs after the intervention were 17% (95% confidence interval [CI], 6%-29%) for the total study population and 25% (95% CI, 11%-39%) and 8% (95% CI, -5% to 21%) for the Hb groups 10 to 13 and more than 13 g/dL, respectively. In the postintervention period, 46% of the eligible patients (Hb level, 10-13 g/dL) actually received EPO. The transfusion rate in the EPO group was lower compared to the non-EPO group: 14 and 50%, respectively (p < 0.01). CONCLUSION: Introduction of a preoperative EPO protocol reduced the transfusion rate in THA patients in daily clinical practice. The reduction must be seen as part of a multifaceted blood management program, in which increased awareness of blood transfusion contributes simultaneously and substantially to the reduction in transfusion rate.
Hieronymus J Doodeman; Ingrid M M van Haelst; Toine C G Egberts; Martin Bennis; Han S Traast; Wouter W van Solinge; Cor J Kalkman; Wilton A van Klei
Related Documents :
23701829 - Outcomes of open temporomandibular joint surgery following failure to improve after art...
24599179 - Effectiveness of hyalobarrier and seprafilm to prevent polypropylene mesh shrinkage: a ...
12756099 - Phase 1/2 pilot study of methotrexate-laurocapram topical gel for the treatment of pati...
23588709 - A prospective, randomized, single-blind trial of 5-mm versus 3-mm ports for laparoscopi...
24393169 - Cardiovascular medication use following percutaneous coronary intervention: the austral...
24806319 - Microvascular anastomosis using ankaferd blood stopper: demonstration of long-term hist...
20041929 - An open study of maintenance antibiotic therapy for chronic antibiotic-dependent pouchi...
12271299 - Treatment of toxic epidermal necrolysis with intravenous immunoglobulin in children.
21602689 - Safety of infliximab in 10 years of clinical practice.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-12
Journal Detail:
Title:  Transfusion     Volume:  -     ISSN:  1537-2995     ISO Abbreviation:  Transfusion     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 American Association of Blood Banks.
Department of Clinical Pharmacy, Department of Anesthesiology, Medical Center Alkmaar, Alkmaar, the Netherlands; Department of Clinical Pharmacy, Department of Clinical Chemistry and Haematology, Department of Anesthesiology, Intensive Care and Emergency Medicine, University Medical Center; Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fronto-striatal functional connectivity during response inhibition in alcohol dependence.
Next Document:  Quality of life of nigerian informal caregivers of community-dwelling stroke survivors.