| The effect of preoperative aspirin-free interval on red blood cell transfusion requirements in cardiac surgical patients. | |
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MedLine Citation:
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PMID: 11854879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare red blood cell transfusion in first-time coronary artery surgery patients who stopped taking aspirin < or = 2 days, 3 to 7 days, or >7 days preoperatively. DESIGN: Observational study. SETTING: University-affiliated teaching hospital. PARTICIPANTS: Adult patients (n = 797) undergoing first-time coronary artery surgery on cardiopulmonary bypass who were not receiving other anticoagulant or antiplatelet drugs before surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Patients were divided into 4 groups based on days since last ingestion of aspirin. Blood products transfused in the groups were (aspirin < or =2 days) (n = 140) 2.2 +/- 4 U of red cell concentrate (RCC) (mean +/- SD), 1.4 +/- 3 U of fresh frozen plasma (FFP), and 2.7 +/- 6 U of platelets; (aspirin 3 to 5 days) (n = 255), 1.5 +/- 2 U of RCC, 0.8 +/- 2 U of FFP, and 1.6 +/- 4 U of platelets; (aspirin 6 to 7 days) (n = 215), 1.6 +/- 3 U of RCC, 0.9 +/- 3 U of FFP, and 1.5 +/- 3 U of platelets; and (aspirin >7 days) (n = 187), 1.3 +/- 2 U of RCC; 0.6 +/- 2 U of FFP, and 0.9 +/- 2 U of platelets. CONCLUSION: Patients who stop taking aspirin < or =2 s preoperatively have increased allogenic red blood cell transfusion requirements perioperatively. Patients who stop taking aspirin 3 to 7 days preoperatively have little or no increased requirement for allogenic red blood cell transfusion. |
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Authors:
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William M Weightman; Neville M Gibbs; Crispin R Weidmann; Mark A J Newman; Diane E Grey; Matthew R Sheminant; Wendy N Erber |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiothoracic and vascular anesthesia Volume: 16 ISSN: 1053-0770 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-03-07 Completed Date: 2002-11-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: United States |
Other Details:
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Languages: eng Pagination: 54-8 Citation Subset: IM |
Copyright Information:
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Copyright 2002, Elsevier Science (USA). All rights reserved. |
Affiliation:
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Departments of Anaesthesia and Cardiothoracic Surgery, Sir Charles Gairdner Hospital, and PathCentre, Nedlands, Western Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aspirin
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administration & dosage* Blood Loss, Surgical Coronary Artery Bypass* Erythrocyte Transfusion* Female Hemoglobins / analysis Humans Male Middle Aged Plasma Platelet Aggregation Inhibitors / administration & dosage* Platelet Count Platelet Transfusion Preoperative Care Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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