| The effect of preoperative 5-fluorouracil on colonic healing: an experimental study. | |
| | |
MedLine Citation:
|
PMID: 11813589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND/AIMS: After curative resection for colorectal carcinoma there is a high recurrence rate and neoadjuvant chemotherapy may be useful in some patients. Very little is known about the effect of preoperative 5-fluorouracil on the healing of colon anastomosis. The aim of this study was to evaluate the effect of 5-fluorouracil on colonic healing when the time interval between the last injection and operation was shortened to 24 hours. METHODOLOGY: Thirty-six male Wistar rats with a median weight of 185 g (range: 165-200 g) were divided into three groups: 1) control group (n = 12); 2) sham group (n = 12) which received saline intraperitoneally, and 3) study group (n = 12) which received 5-fluorouracil intraperitoneally (20 mg/kg-1). All injections were given intraperitoneally for 5 days and the last dose was injected 24 hours before operation. RESULTS: The mortality rate (22.7%) and anastomotic complications (29.4%) were increased in the 5-fluorouracil group, compared with the control or saline groups (P < 0.05). The anastomotic bursting pressure in rats having 5-fluorouracil treatment (27 mm Hg) was significantly lower from both the control (55 mm Hg) and saline (84 mm Hg) groups on postoperative day 3 (P < 0.05). Both myeloperoxidase and hydroxyproline contents were also significantly lower than the other groups (P < 0.05). CONCLUSIONS: Colonic healing was impaired and mortality rate was increased when intraperitoneal 5-fluorouracil treatment was repeated until 24 hours before operation. |
| | |
Authors:
|
A D Bozdag; Y Peker; H Derici; C Gürkök; M Ozgönül |
Related Documents
:
|
8277179 - Treatment with albendazole for intestinal disease due to enterocytozoon bieneusi in pat... 3046699 - Management of major colonic haemorrhage. 18302069 - Influence of gum chewing on return of gastrointestinal function after gastric abdominal... 19707769 - Ct colonography with minimal bowel preparation: evaluation of tagging quality, patient ... 4008909 - Outcome of toxic dilatation in ulcerative and crohn's colitis. 9493989 - The bianchi procedure in a patient with jejunal atresia. 20578609 - Is it possible to reduce rates of placenta praevia? 21521889 - Transcervical drainage for descending necrotizing mediastinitis may be sufficient. 18416219 - Low molecular starch versus gelatin plasma expander during cpb: does it make a difference? |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Hepato-gastroenterology Volume: 48 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2001 Nov-Dec |
Date Detail:
|
Created Date: 2002-01-29 Completed Date: 2002-06-26 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
|
Languages: eng Pagination: 1631-4 Citation Subset: IM |
Affiliation:
|
Izmir Atatürk Training and Research Hospital, Izmir, Turkey. bozdag@egenet.com.tr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anastomosis, Surgical Animals Antineoplastic Agents / pharmacology* Colectomy* Fluorouracil / pharmacology* Male Preoperative Care Rats Rats, Wistar Time Factors Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bleeding Meckel's diverticulum in an adult.
Next Document: Current trends in screening and secondary prevention of colorectal cancer.