Document Detail

The effect of preoperative 5-fluorouracil on colonic healing: an experimental study.
MedLine Citation:
PMID:  11813589     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: After curative resection for colorectal carcinoma there is a high recurrence rate and neoadjuvant chemotherapy may be useful in some patients. Very little is known about the effect of preoperative 5-fluorouracil on the healing of colon anastomosis. The aim of this study was to evaluate the effect of 5-fluorouracil on colonic healing when the time interval between the last injection and operation was shortened to 24 hours. METHODOLOGY: Thirty-six male Wistar rats with a median weight of 185 g (range: 165-200 g) were divided into three groups: 1) control group (n = 12); 2) sham group (n = 12) which received saline intraperitoneally, and 3) study group (n = 12) which received 5-fluorouracil intraperitoneally (20 mg/kg-1). All injections were given intraperitoneally for 5 days and the last dose was injected 24 hours before operation. RESULTS: The mortality rate (22.7%) and anastomotic complications (29.4%) were increased in the 5-fluorouracil group, compared with the control or saline groups (P < 0.05). The anastomotic bursting pressure in rats having 5-fluorouracil treatment (27 mm Hg) was significantly lower from both the control (55 mm Hg) and saline (84 mm Hg) groups on postoperative day 3 (P < 0.05). Both myeloperoxidase and hydroxyproline contents were also significantly lower than the other groups (P < 0.05). CONCLUSIONS: Colonic healing was impaired and mortality rate was increased when intraperitoneal 5-fluorouracil treatment was repeated until 24 hours before operation.
A D Bozdag; Y Peker; H Derici; C Gürkök; M Ozgönül
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  48     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2001 Nov-Dec
Date Detail:
Created Date:  2002-01-29     Completed Date:  2002-06-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1631-4     Citation Subset:  IM    
Izmir Atatürk Training and Research Hospital, Izmir, Turkey.
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MeSH Terms
Anastomosis, Surgical
Antineoplastic Agents / pharmacology*
Fluorouracil / pharmacology*
Preoperative Care
Rats, Wistar
Time Factors
Wound Healing / drug effects*
Reg. No./Substance:
0/Antineoplastic Agents; 51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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