| The effect of prenatal and postnatal dietary exposures on childhood development of atopic disease. | |
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MedLine Citation:
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PMID: 20164763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Prenatal and early life dietary factors may influence asthma and allergic disease development. We review recent studies and consensus statements regarding the effects of prenatal/early life dietary exposures on atopic disease. RECENT FINDINGS: The American Academy of Pediatrics consensus statement highlighted the inadequacy of evidence for pregnancy antigen avoidance diets or delay of infant complementary foods beyond 4-6 months. Recent studies raise the question of whether early food introduction may promote tolerance, though controlled trials are pending. A recent meta-analysis suggested that antioxidants may protect against the development of atopy. Furthermore, some of the conflicting results on the effects of vitamin E may be related to variability in the isoforms prevalent in local diet. Recent studies of vitamin D similarly suggest that it may be protective, though this remains controversial. Finally, prenatal methyl donor exposure promoted the development of allergy in an animal model. SUMMARY: There are conflicting data on the effects of most prenatal and early childhood dietary exposures on childhood atopic disease. Longitudinal prenatal/birth cohort studies with prospective measurements and clinical supplementation trials of promising dietary factors will be needed to make reliable recommendations in this vulnerable population of pregnant women and their infants. |
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Authors:
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Rachel Robison; Rajesh Kumar |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in allergy and clinical immunology Volume: 10 ISSN: 1473-6322 ISO Abbreviation: Curr Opin Allergy Clin Immunol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100936359 Medline TA: Curr Opin Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 139-44 Citation Subset: IM |
Affiliation:
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Division of Allergy and Clinical Immunology, Children's Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants* Consensus Diet / adverse effects* Environmental Exposure / adverse effects* Female Humans Hypersensitivity, Immediate / etiology*, prevention & control Meta-Analysis as Topic Pediatrics* Postnatal Care Pregnancy Prenatal Care Societies, Medical United States Vitamin D |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 1406-16-2/Vitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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