Document Detail

The effect of prenatal exposure on total IgE at birth and sensitization at twelve months and four years of age: The PIAMA study.
MedLine Citation:
PMID:  15693906     Owner:  NLM     Status:  MEDLINE    
There is increasing evidence that the development of the fetal immune system can be influenced by environmental exposure in utero. We investigated whether prenatal exposure is associated with a high neonatal total IgE level and sensitization at the age of 1 and 4 yr. Data from 1027 infants were collected in a Dutch birth cohort study (PIAMA study). Total IgE was measured in heel prick blood collected in the first week of life. Sensitization was defined as a specific IgE level in serum of > or =0.35 IU/ml against house dust mite, cat, dog, milk or egg. Logistic regression analysis was performed to study independent relationships between risk factors and a high neonatal total IgE (> or =0.50 IU/ml) or sensitization. A high neonatal total IgE was found in 12.2% of boys and 6.2% of girls. A dog at home during pregnancy was negatively associated with a high neonatal total IgE [odds ratio (95% CI) 0.5 (0.2-1.0)]. A cat at home [OR 0.6 (0.4-1.0) and maternal smoking (OR 0.4 (0.2-1.0)] were negatively associated with sensitization at 12 months, but not at 4 yr. The presence of older siblings, season of birth, birth weight, mode of delivery, gestational age and maternal age were not associated with a high neonatal total IgE or sensitization. The higher total IgE level and prevalence of sensitization at 4 yr in boys compared with girls was only present in children from allergic mothers. Our results suggest a short-lasting protective effect of prenatal exposure to pets on total IgE at birth and early sensitization.
Marjan Kerkhof; Alet Wijga; Henriëtte A Smit; Johan C de Jongste; Rob C Aalberse; Bert Brunekreef; Jorrit Gerritsen; Dirkje S Postma;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  16     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-07     Completed Date:  2005-08-30     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  10-8     Citation Subset:  IM    
Department of Epidemiology, University of Groningen, Groningen, The Netherlands.
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MeSH Terms
Age Factors
Animals, Domestic / immunology
Child, Preschool
Cohort Studies
Environmental Exposure / adverse effects
Hypersensitivity, Immediate / epidemiology*,  immunology
Immunoglobulin E / blood*,  immunology
Infant, Newborn
Netherlands / epidemiology
Odds Ratio
Prenatal Exposure Delayed Effects*
Prospective Studies
Risk Factors
Sex Hormone-Binding Globulin
Reg. No./Substance:
0/Sex Hormone-Binding Globulin; 37341-29-0/Immunoglobulin E

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