| The effect of prenatal exposure to a repeat high dose of toluene in the fetal rat. | |
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MedLine Citation:
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PMID: 18848622 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Solvent abuse during pregnancy results in a clinical pattern of adverse outcomes including deafness. The aim of this project was to determine whether high doses of toluene for a short duration during pregnancy produced adverse outcomes in the fetal rat. Pregnant rats were given either 1250 mg/kg of toluene or peanut oil by gavage from gestation day 16-19. The study demonstrated that administration of toluene at the dose used did not result in significant maternal toxicity. However, some maternal renal pathology was noted. There was no significant difference in placental or fetal weights nor was there a significant difference in the number of external or skeletal malformations of fetuses between treatment and control groups. Treated fetuses had an increased frequency and severity of enlarged renal pelveses. A pattern of accelerated development in the upper mid-turn and sometimes apical turns in the treated fetal cochleas was observed. This accelerated development suggests that toluene may induce excessive cell death resulting in premature maturation of the cochlea. |
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Authors:
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Rachelle Warner; Helen E Ritchie; Patricia Woodman; Diana Oakes; Mohsen Pourghasem |
Publication Detail:
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Type: Journal Article Date: 2008-09-19 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 26 ISSN: 0890-6238 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2008 Nov-Dec |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2009-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 267-72 Citation Subset: IM |
Affiliation:
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Faculty of Medicine, School of Biomedical Sciences, University of Sydney, P.O. Box 170, Lidcombe, NSW 1825, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced Animals Apoptosis / drug effects Bone and Bones / abnormalities Cochlea / drug effects*, pathology Female Fetal Weight / drug effects Fetus / drug effects* In Situ Nick-End Labeling Male Rats Rats, Sprague-Dawley Toluene / toxicity* |
| Chemical | |
Reg. No./Substance:
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108-88-3/Toluene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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