Document Detail


The effect of prenatal exposure to a repeat high dose of toluene in the fetal rat.
MedLine Citation:
PMID:  18848622     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Solvent abuse during pregnancy results in a clinical pattern of adverse outcomes including deafness. The aim of this project was to determine whether high doses of toluene for a short duration during pregnancy produced adverse outcomes in the fetal rat. Pregnant rats were given either 1250 mg/kg of toluene or peanut oil by gavage from gestation day 16-19. The study demonstrated that administration of toluene at the dose used did not result in significant maternal toxicity. However, some maternal renal pathology was noted. There was no significant difference in placental or fetal weights nor was there a significant difference in the number of external or skeletal malformations of fetuses between treatment and control groups. Treated fetuses had an increased frequency and severity of enlarged renal pelveses. A pattern of accelerated development in the upper mid-turn and sometimes apical turns in the treated fetal cochleas was observed. This accelerated development suggests that toluene may induce excessive cell death resulting in premature maturation of the cochlea.
Authors:
Rachelle Warner; Helen E Ritchie; Patricia Woodman; Diana Oakes; Mohsen Pourghasem
Publication Detail:
Type:  Journal Article     Date:  2008-09-19
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  26     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  IM    
Affiliation:
Faculty of Medicine, School of Biomedical Sciences, University of Sydney, P.O. Box 170, Lidcombe, NSW 1825, Australia.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced
Animals
Apoptosis / drug effects
Bone and Bones / abnormalities
Cochlea / drug effects*,  pathology
Female
Fetal Weight / drug effects
Fetus / drug effects*
In Situ Nick-End Labeling
Male
Rats
Rats, Sprague-Dawley
Toluene / toxicity*
Chemical
Reg. No./Substance:
108-88-3/Toluene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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