Document Detail


The effect of pregnancy in Parkinson's disease.
MedLine Citation:
PMID:  10634252     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy in patients with Parkinson's disease (PD) is a rare occurrence. Previous reports based on retrospective analysis suggest that pregnancy may have a deleterious effect on PD. We describe the effects of pregnancy on the symptomatology of a 33-year-old woman with PD using quantitative neurologic and quality-of-life scales prepartum, intrapartum, and postpartum. During her pregnancy, she was only treated with carbidopa/levodopa. The pregnancy resulted in a normal full-term vaginal delivery of a healthy infant. Significant worsening of this patient's motor symptoms occurred during pregnancy without return to baseline at 15 months postpartum. Pregnancy may exacerbate PD and may have a long-term negative impact on the course of the illness. This report may assist physicians in the counseling of patients with young-onset PD who wish to consider pregnancy.
Authors:
L M Shulman; A Minagar; W J Weiner
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  15     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-10     Completed Date:  2000-02-10     Revised Date:  2009-10-06    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  132-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Miami School of Medicine, Florida 33136, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiparkinson Agents / administration & dosage,  adverse effects
Carbidopa / administration & dosage,  adverse effects
Disease Progression
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Combinations
Female
Follow-Up Studies
Humans
Infant, Newborn
Levodopa / administration & dosage,  adverse effects
Neurologic Examination / drug effects
Parkinson Disease / diagnosis*,  drug therapy
Pregnancy
Pregnancy Complications / diagnosis*,  drug therapy
Quality of Life
Chemical
Reg. No./Substance:
0/Antiparkinson Agents; 0/Drug Combinations; 0/Levodopa; 0/carbidopa, levodopa drug combination; 38821-49-7/Carbidopa
Comments/Corrections
Comment In:
Mov Disord. 2002 Mar;17(2):428-9   [PMID:  11921143 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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