| The effect of pregnancy on glomerular filtration rate and salt and water reabsorption in the rat. | |
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MedLine Citation:
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PMID: 7320910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Glomerular filtration rate (G.F.R.) and salt and water reabsorption were measured in age-matched (12- to 13-week-old) virgin rats and rats at different stages of pregnancy and infused with saline at 37.5 and 200 microliters/min. 2. G.F.R. and salt and water reabsorption were significantly higher in early pregnancy and remained at steady, high values until at least mid-pregnancy. G.F.R. was slightly lower close to term, but sodium and water reabsorption remained significantly enhanced. 3. Significant expansion of extracellular fluid volume (e.c.f.v) was first apparent during mid-pregnancy, indicating that e.c.f.v. expansion could not be directly responsible for the early increase in G.F.R. 4. Proximal tubules were significantly elongated 5- days after mating until term, indicating that an increased reabsorptive area in the proximal tubule may be at least partly responsible for the increased reabsorption in pregnancy. |
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Authors:
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J C Atherton; S C Pirie |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of physiology Volume: 319 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1981 |
Date Detail:
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Created Date: 1982-03-22 Completed Date: 1982-03-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 153-64 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Animals Extracellular Space / metabolism Female Glomerular Filtration Rate Kidney / metabolism* Kidney Tubules, Proximal / metabolism Pregnancy Pregnancy, Animal* Rats Sodium Chloride / metabolism* Time Factors Water / metabolism* |
| Chemical | |
Reg. No./Substance:
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7647-14-5/Sodium Chloride; 7732-18-5/Water |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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