Document Detail

The effect of pregnancy on glomerular filtration rate and salt and water reabsorption in the rat.
MedLine Citation:
PMID:  7320910     Owner:  NLM     Status:  MEDLINE    
1. Glomerular filtration rate (G.F.R.) and salt and water reabsorption were measured in age-matched (12- to 13-week-old) virgin rats and rats at different stages of pregnancy and infused with saline at 37.5 and 200 microliters/min. 2. G.F.R. and salt and water reabsorption were significantly higher in early pregnancy and remained at steady, high values until at least mid-pregnancy. G.F.R. was slightly lower close to term, but sodium and water reabsorption remained significantly enhanced. 3. Significant expansion of extracellular fluid volume (e.c.f.v) was first apparent during mid-pregnancy, indicating that e.c.f.v. expansion could not be directly responsible for the early increase in G.F.R. 4. Proximal tubules were significantly elongated 5- days after mating until term, indicating that an increased reabsorptive area in the proximal tubule may be at least partly responsible for the increased reabsorption in pregnancy.
J C Atherton; S C Pirie
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  319     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1981  
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  153-64     Citation Subset:  IM    
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MeSH Terms
Extracellular Space / metabolism
Glomerular Filtration Rate
Kidney / metabolism*
Kidney Tubules, Proximal / metabolism
Pregnancy, Animal*
Sodium Chloride / metabolism*
Time Factors
Water / metabolism*
Reg. No./Substance:
7647-14-5/Sodium Chloride; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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