Document Detail

The effect of pregabalin on preoperative anxiety and sedation levels: a dose-ranging study.
MedLine Citation:
PMID:  19299776     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pregabalin is a gabapentinoid compound, which has been alleged to possess anxiolytic, analgesic, and anticonvulsant properties. We hypothesized that premedication with oral pregabalin would produce dose-related reductions in acute (state) anxiety and increases in sedation (sleepiness) before induction of general anesthesia. A secondary objective was to determine if premedication with pregabalin would reduce postoperative pain.
METHODS: One hundred eight ASA I-III outpatients undergoing elective surgery were randomly assigned to one of the four premedication treatment groups: 1) control group received placebo capsules, 2) pregabalin 75 group received pregabalin 75 mg, po, 3) pregabalin 150 group received pregabalin 150 mg, po, and 4) pregabalin 300 group received pregabalin 300 mg, po. The effects of the study drug on the patients' level of anxiety, sedation, and pain were assessed at baseline (immediately before study drug administration), at 30 and 60 min after drug administration, and immediately before induction of anesthesia, as well as at 30-min intervals in the postanesthesia care unit (PACU) using standardized 11-point verbal rating scales, with 0 = none to 10 = maximal effect. The need for postoperative opioid analgesic medication, incidence of nausea and vomiting, requirement for rescue antiemetics, and times to discharge from the PACU and hospital, as well as the patients' quality of recovery scores, and late recovery outcomes (e.g., resumption of dietary intake and recovery of bowel function) were assessed at a 7-day follow-up interview.
RESULTS: Demographic characteristics, times between study drug administration to anesthetic induction, type of surgical procedures, duration of anesthesia, PACU and hospital discharge time, as well as the requirement for fentanyl in the PACU, did not differ among the four study groups. Anxiety levels remained unchanged during the preoperative evaluation period, and did not differ among the four study groups. Sedation scores were significantly higher in the pregabalin 300 group at the preinduction assessment interval and at 90 and 120 min after surgery compared with the control group (5 +/- 3 vs 3 +/- 2, 7 +/- 4 vs 5 +/- 3, 8 +/- 4 vs 4 +/- 4, respectively, P < 0.05).
CONCLUSION: Preoperative pregabalin administration (75-300 mg po) increased perioperative sedation in a dose-related fashion, but failed to reduce preoperative state anxiety, postoperative pain, or to improve the recovery process after minor elective surgery procedures.
Paul F White; Burcu Tufanogullari; Jimmie Taylor; Kevin Klein
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  108     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-04-08     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1140-5     Citation Subset:  AIM; IM    
Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9068, USA.
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MeSH Terms
Administration, Oral
Analgesics / administration & dosage*,  adverse effects
Analgesics, Opioid / therapeutic use
Anti-Anxiety Agents / administration & dosage*,  adverse effects
Antiemetics / therapeutic use
Anxiety / etiology,  prevention & control*
Dose-Response Relationship, Drug
Double-Blind Method
Fentanyl / therapeutic use
Hypnotics and Sedatives / administration & dosage*,  adverse effects
Length of Stay
Middle Aged
Pain Measurement
Pain, Postoperative / prevention & control*
Postoperative Nausea and Vomiting / etiology,  prevention & control
Preanesthetic Medication*
Recovery of Function
Sleep / drug effects*
Surgical Procedures, Elective / psychology
Time Factors
gamma-Aminobutyric Acid / administration & dosage,  adverse effects,  analogs & derivatives*
Reg. No./Substance:
0/Analgesics; 0/Analgesics, Opioid; 0/Anti-Anxiety Agents; 0/Antiemetics; 0/Capsules; 0/Hypnotics and Sedatives; 437-38-7/Fentanyl; 55JG375S6M/pregabalin; 56-12-2/gamma-Aminobutyric Acid
Comment In:
Anesth Analg. 2009 Apr;108(4):1058-61   [PMID:  19299761 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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