Document Detail

The effect of prebiotics in the management of neonatal hyperbilirubinaemia.
MedLine Citation:
PMID:  19555446     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Breast milk oligosaccharides such as galacto-oligosaccharides (scGOS) and fructo-oligosaccharides (lcFOS) can influence the intestinal microbial flora. The latter, in turn, can modulate several intestinal and extraintestinal functions, including bilirubin metabolism. Supplementing infant formula with a prebiotic mixture might then be a novel and safe intervention to manage mild neonatal hyperbilirubinaemia. AIM: To investigate the effect of dietary supplementation with prebiotics on moderate hyperbilirubinaemia in healthy, term infants. METHODS: A prospective, double-blind, clinical trial was performed on seventy-six consecutive newborns who were randomly assigned to receive a formula containing 0.8 g/dL of a mixture from scGOS and lcFOS (ratio 9:1), or maltodextrines as placebo for 28 days. Bilirubin levels were determined by the transcutaneous bilirubin measurement within 2 h after birth (T1), at 24, 48 and 72 h and at 5, 7, 10 and 28 days of life. The number of stool per day was also recorded. RESULTS: Neonates receiving prebiotics showed a larger number of stools over all the duration of dietary intervention compared to that of those on placebo (Repeated Measures ANOVA p < 0.001; day 28 3.4 +/- 0.0.9 vs 1.7 +/- 0.9, respectively; Dunn test p < 0.05). Neonates whose formula was supplemented with prebiotics showed a lower transcutaneous bilirubin that was statistically significant from 72 h of life (5.46 +/- 1.6 vs 7.07 +/- 2.49, post hoc Dunn test, p < 0.05) throughout the duration of the dietary intervention (day 28 2.41 +/- 0.4 vs 2.85 +/- 0.5, post hoc Dunn test, p < 0.05). CONCLUSION: The addition of prebiotics to standard infant diet might represent a novel strategy to help control neonatal hyperbilirubinaemia.
M Bisceglia; F Indrio; G Riezzo; V Poerio; U Corapi; F Raimondi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-06-23
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  98     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-21     Completed Date:  2009-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1579-81     Citation Subset:  IM    
Department of Pediatrics, Ospedale San Giovanni di Dio Via XXV Aprile, Crotone, Italy.
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MeSH Terms
Analysis of Variance
Bilirubin / blood
Dietary Supplements*
Double-Blind Method
Hyperbilirubinemia, Neonatal / therapy*
Infant Formula / chemistry
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Oligosaccharides / therapeutic use
Polysaccharides / therapeutic use
Prospective Studies
Reg. No./Substance:
0/Oligosaccharides; 0/Polysaccharides; 0/Prebiotics; 635-65-4/Bilirubin; 9050-36-6/maltodextrin

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