Document Detail


The effect of potassium canrenoate (Aldactone) on the norepinephrine metabolism and potassium ionic currents of the heart.
MedLine Citation:
PMID:  6302766     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Under experimental conditions, potassium canrenoate causes a significant increase in [3H]norepinephrine (NE) uptake by the heart, although the NE content remains unchanged. The increased NE uptake and unchanged NE content indicate an augmented NE turnover caused by the drug. In saluretic-pretreated animals, the intracellular hypopotassemia can be restored by Aldactone. This effect can be explained by the inhibition of the outward potassium current. When we simulated the pathophysiological conditions of the acute phase of myocardial infarction by using a K+-rich superfusate to partially depolarize the myocardial cells, slow action potentials were elicited by NE in isolated papillary muscles. Our microelectrode experiments revealed that Aldactone, by its blocking effect on the potassium conductance, increases the duration of the slow action potentials and decreases the threshold NE concentration required to elicit the slow responses. However, in clinical conditions with a higher level of circulating catecholamine and/or hyperpotassemia, the administration of the drug has a considerable risk of provoking arrhythmias.
Authors:
Z Antalóczy; M Sebeszta; I Préda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in myocardiology     Volume:  3     ISSN:  0270-4056     ISO Abbreviation:  Adv Myocardiol     Publication Date:  1982  
Date Detail:
Created Date:  1983-06-23     Completed Date:  1983-06-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8000285     Medline TA:  Adv Myocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Canrenoate Potassium / pharmacology*
Heart Atria / drug effects
Heart Ventricles / drug effects
Ion Channels / drug effects*
Muridae
Myocardial Contraction / drug effects*
Myocardium / metabolism*
Norepinephrine / metabolism*
Pargyline / pharmacology
Potassium / metabolism
Pregnadienes / pharmacology*
Spironolactone / pharmacology
Chemical
Reg. No./Substance:
0/Ion Channels; 0/Pregnadienes; 2181-04-6/Canrenoate Potassium; 51-41-2/Norepinephrine; 52-01-7/Spironolactone; 555-57-7/Pargyline; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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