Document Detail

The effect of positive end-expiratory pressure on regional pulmonary perfusion during acute lung injury.
MedLine Citation:
PMID:  7920976     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine whether positive end-expiratory pressure (PEEP) would change the altered regional pulmonary perfusion pattern caused by oleic acid (OA)-induced acute lung injury was the aim of this study. Our hypothesis was that fixed intravascular obstruction would not be affected by PEEP, leaving the perfusion pattern unchanged if this was the principal cause of perfusion redistribution after lung injury. METHODS: Regional measurements of pulmonary perfusion and lung water concentration (LWC) were obtained both before and after lung injury and before and after PEEP (10 cm H2O) with the nuclear medicine imaging technique of positron emission tomography after injections of H2 15O in 7 supine anesthetized dogs. Four animals were also treated with meclofenamate to enhance perfusion redistribution after acute lung injury. RESULTS: The application of PEEP before lung injury did not significantly affect the regional perfusion pattern. After administration of OA, LWC increased and fractional flow (without PEEP) decreased to the most edematous lung regions, consistent with perfusion redistribution. With the reapplication of PEEP, the perfusion pattern reverted toward the baseline pattern. The magnitude of this effect was roughly proportional to the effect of PEEP on regional inflation (r = .53), as evidenced by changes in LWC. CONCLUSIONS: The reversibility with PEEP of the perfusion pattern caused by acute lung injury suggests that fixed intravascular obstruction is not the principal determinant of perfusion redistribution after OA-induced injury.
D P Schuster; D K Howard
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of critical care     Volume:  9     ISSN:  0883-9441     ISO Abbreviation:  J Crit Care     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-04     Completed Date:  1994-11-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  100-10     Citation Subset:  IM    
Department of Internal Medicine, Washington University Medical School, St Louis, Missouri 63110.
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MeSH Terms
Acute Disease
Disease Models, Animal
Extravascular Lung Water / radionuclide imaging
Meclofenamic Acid / pharmacology
Oleic Acid
Oleic Acids
Positive-Pressure Respiration / adverse effects,  methods*
Pulmonary Circulation*
Pulmonary Edema / chemically induced,  physiopathology*,  radionuclide imaging,  therapy*
Tomography, Emission-Computed
Grant Support
Reg. No./Substance:
0/Oleic Acids; 112-80-1/Oleic Acid; 644-62-2/Meclofenamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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