Document Detail

The effect of positive end expiratory pressure on the respiratory profile during one-lung ventilation for thoracotomy.
MedLine Citation:
PMID:  17156223     Owner:  NLM     Status:  MEDLINE    
Summary In this randomised controlled trial we examined the effects of four different levels of positive end expiratory pressure (PEEP at 0, 5, 8 or 10 cmH(2)O), added to the dependent lung, on respiratory profile and oxygenation during one lung ventilation. Forty-six patients were recruited to receive one of the randomised PEEP levels during one lung ventilation. We did not find significant differences in lung compliance, intra-operative or postoperative oxygenation amongst the four different groups. However, the physiological deadspace to tidal volume ventilation ratio was significantly lower in the 8 cmH(2)O PEEP group compared with the other levels of PEEP (p < 0.0001). We concluded that the use of PEEP (< or =10 cmH(2)O) during one lung ventilation does not clinically improve lung compliance, intra-operative or postoperative oxygenation despite a statistically significant reduction in the physiological deadspace to tidal volume ratio.
L M C Leong; S Chatterjee; F Gao
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  62     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  23-6     Citation Subset:  AIM; IM    
Department of Anaesthesia, Alexandra Hospital, Redditch B98 7UB, UK.
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MeSH Terms
Intraoperative Period
Lung / physiopathology*
Lung Compliance / physiology
Middle Aged
Oxygen / physiology
Positive-Pressure Respiration / methods*
Postoperative Period
Respiratory Dead Space / physiology
Thoracotomy / methods*
Tidal Volume / physiology
Reg. No./Substance:

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