Document Detail

The effect of porosity on drug release kinetics from vancomycin microsphere/calcium phosphate cement composites.
MedLine Citation:
PMID:  21948487     Owner:  NLM     Status:  MEDLINE    
The influence of porosity on release profiles of antibiotics from calcium phosphate composites was investigated to optimize the duration of treatment. We hypothesized, that by the encapsulation of vancomycin-HCl into biodegradable microspheres prior admixing to calcium phosphate bone cement, the influence of porosity of the cement matrix on vancomycin release could be reduced. Encapsulation of vancomycin into a biodegradable poly(lactic co-glycolic acid) copolymer (PLGA) was performed by spray drying; drug-loaded microparticles were added to calcium phosphate cement (CPC) at different powder to liquid ratios (P/L), resulting in different porosities of the cement composites. The effect of differences in P/L ratio on drug release kinetics was compared for both the direct addition of vancomycin-HCl to the cement liquid and for cement composites modified with vancomycin-HCl-loaded microspheres. Scanning electron microscopy (SEM) was used to visualize surface and cross section morphology of the different composites. Brunauer, Emmett, and Teller-plots (BET) was used to determine the specific surface area and pore size distribution of these matrices. It could be clearly shown, that variations in P/L ratio influenced both the porosity of cement and vancomycin release profiles. Antibiotic activity during release study was successfully measured using an agar diffusion assay. However, vancomycin-HCl encapsulation into PLGA polymer microspheres decreased porosity influence of cement on drug release while maintaining antibiotic activity of the embedded substance.
Julia Schnieders; Uwe Gbureck; Elke Vorndran; Michael Schossig; Thomas Kissel
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Publication Detail:
Type:  Journal Article     Date:  2011-09-21
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  99     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-14     Completed Date:  2012-03-22     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-8     Citation Subset:  IM    
Copyright Information:
2011 Wiley Periodicals, Inc.
Department of Pharmaceutics and Biopharmacy, Philipps-University Marburg, Ketzerbach 63, 35032 Marburg, Germany.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage,  pharmacokinetics
Bone Cements / chemistry*
Calcium Phosphates / administration & dosage*
Drug Delivery Systems*
Microscopy, Electron, Scanning / methods
Osteomyelitis / drug therapy
Staphylococcus aureus / metabolism
Vancomycin / administration & dosage*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bone Cements; 0/Calcium Phosphates; 0/Hydroxyapatites; 0/Powders; 1404-90-6/Vancomycin; 97Z1WI3NDX/calcium phosphate
Erratum In:
J Biomed Mater Res B Appl Biomater. 2012 Apr;100(3):890

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