Document Detail

The effect of poorly absorbed solute on intestinal absorption.
MedLine Citation:
PMID:  2125743     Owner:  NLM     Status:  MEDLINE    
To determine the effects of poorly absorbed solute on intestinal absorption, the urinary recovery of ingested lactulose, L-rhamnose, D-xylose, and 3-O-methyl-D-glucose was measured after simultaneous ingestion of various 'loads' of mannitol given in iso-osmolar solution. Mannitol reduced intestinal uptake of the poorly absorbed test sugars, lactulose and L-rhamnose; uptake of D-xylose and 3-O-methyl-D-glucose, which are absorbed by carrier-mediated transport largely from the jejunum, was less affected. The dose-response effect of mannitol on the absorption of L-rhamnose was approximately exponential; doses of 5, 10, and 20 g mannitol reduced the average urinary excretion of L-rhamnose by 34.7%, 51.7%, and 61.2%, respectively. In this respect, an osmotically equivalent load of lactulose, ingested as 'solute', was approximately twice as effective as mannitol in reducing L-rhamnose absorption, probably because lactulose is more poorly absorbed than mannitol (less than 1.0% versus 32-41%). Ingestion of other poorly absorbed solutes such as raffinose, sorbitol, xylitol, magnesium sulphate, and sodium sulphate also significantly depressed the absorption of L-rhamnose; in contrast, more efficiently absorbed solutes, such as sodium chloride, glucose, glycerol, and urea had little effect.
I S Menzies; A P Jenkins; E Heduan; S D Catt; M B Segal; B Creamer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  25     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-02-27     Completed Date:  1991-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1257-64     Citation Subset:  IM    
Dept. of Chemical Pathology and Physiology, St Thomas' Hospital, London, U.K.
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MeSH Terms
Dose-Response Relationship, Drug
Intestinal Absorption / drug effects*
Lactulose / administration & dosage,  metabolism,  pharmacology*
Mannitol / administration & dosage,  pharmacology*
Methylglucosides / metabolism
Middle Aged
Rhamnose / metabolism
Xylose / metabolism
Reg. No./Substance:
0/Methylglucosides; 0/Xylose; 10485-94-6/Rhamnose; 146-72-5/3-O-Methylglucose; 4618-18-2/Lactulose; 69-65-8/Mannitol

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