| The effect of poorly absorbed solute on intestinal absorption. | |
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MedLine Citation:
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PMID: 2125743 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the effects of poorly absorbed solute on intestinal absorption, the urinary recovery of ingested lactulose, L-rhamnose, D-xylose, and 3-O-methyl-D-glucose was measured after simultaneous ingestion of various 'loads' of mannitol given in iso-osmolar solution. Mannitol reduced intestinal uptake of the poorly absorbed test sugars, lactulose and L-rhamnose; uptake of D-xylose and 3-O-methyl-D-glucose, which are absorbed by carrier-mediated transport largely from the jejunum, was less affected. The dose-response effect of mannitol on the absorption of L-rhamnose was approximately exponential; doses of 5, 10, and 20 g mannitol reduced the average urinary excretion of L-rhamnose by 34.7%, 51.7%, and 61.2%, respectively. In this respect, an osmotically equivalent load of lactulose, ingested as 'solute', was approximately twice as effective as mannitol in reducing L-rhamnose absorption, probably because lactulose is more poorly absorbed than mannitol (less than 1.0% versus 32-41%). Ingestion of other poorly absorbed solutes such as raffinose, sorbitol, xylitol, magnesium sulphate, and sodium sulphate also significantly depressed the absorption of L-rhamnose; in contrast, more efficiently absorbed solutes, such as sodium chloride, glucose, glycerol, and urea had little effect. |
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Authors:
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I S Menzies; A P Jenkins; E Heduan; S D Catt; M B Segal; B Creamer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 25 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-02-27 Completed Date: 1991-02-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 1257-64 Citation Subset: IM |
Affiliation:
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Dept. of Chemical Pathology and Physiology, St Thomas' Hospital, London, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-O-Methylglucose Adult Dose-Response Relationship, Drug Female Humans Intestinal Absorption / drug effects* Lactulose / administration & dosage, metabolism, pharmacology* Male Mannitol / administration & dosage, pharmacology* Methylglucosides / metabolism Middle Aged Rhamnose / metabolism Solubility Xylose / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Methylglucosides; 0/Xylose; 10485-94-6/Rhamnose; 146-72-5/3-O-Methylglucose; 4618-18-2/Lactulose; 69-65-8/Mannitol |
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