Document Detail


The effect of polymerized placenta hemoglobin on renal ischemia/reperfusion injury.
MedLine Citation:
PMID:  23152999     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract The goal of this study was to investigate whether hemoglobin-based oxygen carrier (HBOC) attenuated ischemia/reperfusion (I/R)-induced kidney injury. Male SD rats were randomly divided into a sham group, I/R group, and HBOC group (injection of 0.1 gHb/kg PolyPHb). The ischemia was induced by bilateral renal pedicle cross-clamping for 45min. Then the clamp was released to allow 24h reperfusion. Without increasing blood pressure, PolyPHb reduced the blood urea nitrogen and creatinine in plasma and attenuated the tumor necrosis factor-α and interleukin-8 in kidney tissue. Therefore, our findings suggest that PolyPHb could reduce kidney injury after I/R injury, and this effect was probably associated with the depressed inflammatory response.
Authors:
Tao Li; Zhenyu Zhang; Daqin Liao; Yanfang Chen; Chengmin Yang; Xuewen Xu; Jin Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial cells, blood substitutes, and immobilization biotechnology     Volume:  40     ISSN:  1532-4184     ISO Abbreviation:  Artif Cells Blood Substit Immobil Biotechnol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431307     Medline TA:  Artif Cells Blood Substit Immobil Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  396-9     Citation Subset:  IM    
Affiliation:
Laboratory of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu , China.
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