| The effect of polymerized placenta hemoglobin on renal ischemia/reperfusion injury. | |
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MedLine Citation:
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PMID: 23152999 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract The goal of this study was to investigate whether hemoglobin-based oxygen carrier (HBOC) attenuated ischemia/reperfusion (I/R)-induced kidney injury. Male SD rats were randomly divided into a sham group, I/R group, and HBOC group (injection of 0.1 gHb/kg PolyPHb). The ischemia was induced by bilateral renal pedicle cross-clamping for 45min. Then the clamp was released to allow 24h reperfusion. Without increasing blood pressure, PolyPHb reduced the blood urea nitrogen and creatinine in plasma and attenuated the tumor necrosis factor-α and interleukin-8 in kidney tissue. Therefore, our findings suggest that PolyPHb could reduce kidney injury after I/R injury, and this effect was probably associated with the depressed inflammatory response. |
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Authors:
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Tao Li; Zhenyu Zhang; Daqin Liao; Yanfang Chen; Chengmin Yang; Xuewen Xu; Jin Liu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Artificial cells, blood substitutes, and immobilization biotechnology Volume: 40 ISSN: 1532-4184 ISO Abbreviation: Artif Cells Blood Substit Immobil Biotechnol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431307 Medline TA: Artif Cells Blood Substit Immobil Biotechnol Country: England |
Other Details:
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Languages: eng Pagination: 396-9 Citation Subset: IM |
Affiliation:
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Laboratory of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu , China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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