Document Detail


The effect of polymerized placenta hemoglobin on renal ischemia/reperfusion injury.
MedLine Citation:
PMID:  23152999     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract The goal of this study was to investigate whether hemoglobin-based oxygen carrier (HBOC) attenuated ischemia/reperfusion (I/R)-induced kidney injury. Male SD rats were randomly divided into a sham group, I/R group, and HBOC group (injection of 0.1 gHb/kg PolyPHb). The ischemia was induced by bilateral renal pedicle cross-clamping for 45min. Then the clamp was released to allow 24h reperfusion. Without increasing blood pressure, PolyPHb reduced the blood urea nitrogen and creatinine in plasma and attenuated the tumor necrosis factor-α and interleukin-8 in kidney tissue. Therefore, our findings suggest that PolyPHb could reduce kidney injury after I/R injury, and this effect was probably associated with the depressed inflammatory response.
Authors:
Tao Li; Zhenyu Zhang; Daqin Liao; Yanfang Chen; Chengmin Yang; Xuewen Xu; Jin Liu
Related Documents :
14557909 - Selective loss of hilar neurons and impairment of initial learning in rats after repeat...
9383009 - Transfer between atropine-induced spiking in the perirhinal cortex and electrical kindl...
8581479 - Long-term changes in entorhinal-dentate evoked potentials induced by electroconvulsive ...
12423379 - Aida, a class i metabotropic glutamate-receptor antagonist limits kainate-induced hippo...
9352429 - The anticonvulsant effect of deprenyl on pentylenetetrazol-induced seizures in lewis rats.
7898759 - Kainic acid induced seizures cause a marked increase in the expression of neurokinin-3 ...
1289389 - Repeated maternal separation in the neonatal rat: cellular mechanisms contributing to b...
3293099 - Regenerative effects of tetrachlorodecaoxide in bd ix rats after total-body gamma irrad...
19084559 - Expression of c-fos mrna in the basal ganglia associated with contingent tolerance to a...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial cells, blood substitutes, and immobilization biotechnology     Volume:  40     ISSN:  1532-4184     ISO Abbreviation:  Artif Cells Blood Substit Immobil Biotechnol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431307     Medline TA:  Artif Cells Blood Substit Immobil Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  396-9     Citation Subset:  IM    
Affiliation:
Laboratory of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu , China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  [A giant gastrointestinal stromal tumour - a case report].
Next Document:  The mediating role of social environmental factors in the associations between attachment styles and...