| The effect of plunge electrodes during electrical stimulation of cardiac tissue. | |
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MedLine Citation:
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PMID: 11585046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanism for far-field stimulation of cardiac tissue is not known, although many hypotheses have been suggested. This paper explores a new hypothesis: the insulated plunge electrodes used in experiments to map the extracellular potential may affect the transmembrane potential when an electric field is applied to cardiac tissue. Our calculation simulates a 10-mm-diameter sheet of passive tissue with a circular insulated plunge electrode in the middle of it, ranging in diameter from 0.05 to 2 mm. We calculate the transmembrane potential induced by a 500-V/m electric field. Our results show that a transmembrane potential is induced around the electrode in alternating areas of depolarization and hyperpolarization. If the electric field is oriented parallel to the myocardial fibers, the maximum transmembrane potential is 89 mV. A layer of fluid around the electrode increases the transmembrane potential. We conclude that plunge electrodes may introduce artifacts during experiments designed to study the response of the heart to strong electric shocks. |
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Authors:
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D M Langrill; B J Roth |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: IEEE transactions on bio-medical engineering Volume: 48 ISSN: 0018-9294 ISO Abbreviation: IEEE Trans Biomed Eng Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-04 Completed Date: 2001-12-05 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0012737 Medline TA: IEEE Trans Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 1207-11 Citation Subset: IM |
Affiliation:
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Department of Physics, Oakland University, Rochester, MI 48309, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Artifacts Electric Stimulation / instrumentation* Electrodes* Heart / physiology* Membrane Potentials / physiology* Models, Cardiovascular |
| Grant Support | |
ID/Acronym/Agency:
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R01HL57207/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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