| The effect of platelet-rich plasma on the neovascularization of surgically created equine superficial digital flexor tendon lesions. | |
| | |
MedLine Citation:
|
PMID: 20459479 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The repair process of tendon injuries, which are common in both human and equine athletes, is slow and the quality of the repair tissue is often inferior to the original tendon tissue, which frequently leads to re-injury. The relatively poor vascularization of tendons is considered to be one of the reasons for their limited healing potential. Recently, platelet-rich plasma (PRP), an autologous concentrate of platelets, rich in growth factors, has been shown to enhance the repair process of injured tendons. This effect has been ascribed to the high levels of growth factors in PRP, several of which are known to be involved in tendon repair. Among many other growth factors, the vascular endothelial growth factor, a powerful stimulator of angiogenesis, is abundantly present in PRP, suggesting that enhancement of neovascularization might be one of the working mechanisms. In this study, the effect of PRP on neovascularization was studied in experimentally induced tendon injuries using color Doppler ultrasonography and immunological staining of Factor VIII. PRP induced significantly more neovascularization than the placebo treatment until at least 23 weeks after treatment, as detected by both Doppler ultrasonography and Factor VIII staining. Neovascularization might be one of the explanations for the long-lasting effect of a single intratendinous treatment with PRP. |
| | |
Authors:
|
G Bosch; M Moleman; A Barneveld; P R van Weeren; H T M van Schie |
Related Documents
:
|
3927509 - Effects of different anticoagulants on human platelet size distribution and serotonin (... 17014669 - Freeze-dried platelet-rich plasma shows beneficial healing properties in chronic wounds. 19616459 - Effects of platelet-rich plasma on intestinal wound healing in pigs. 14521319 - Assessment of in vitro platelet activation by advia 120 platelet parameters. 6506029 - An assessment of whole blood impedance aggregometry using blood from normal subjects an... 16011959 - Can platelet aggregometry be standardized? 10342049 - Capillary density in patients with systemic sclerosis, as determined by microscopy coun... 11311749 - Synthesis and inhibitory activity towards human leukocyte elastase of new 7alpha-methox... 2476169 - Platelet specific alloantigens on the platelet glycoprotein ia/iia complex. |
Publication Detail:
|
Type: Journal Article Date: 2010-03-10 |
Journal Detail:
|
Title: Scandinavian journal of medicine & science in sports Volume: 21 ISSN: 1600-0838 ISO Abbreviation: Scand J Med Sci Sports Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-07-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9111504 Medline TA: Scand J Med Sci Sports Country: Denmark |
Other Details:
|
Languages: eng Pagination: 554-61 Citation Subset: IM |
Copyright Information:
|
© 2010 John Wiley & Sons A/S. |
Affiliation:
|
Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Poling force analysis in diagonal stride at different grades in cross country skiers.
Next Document: Changes in exercise capacity induced by heart transplantation: prognostic and therapeutic implicatio...