Document Detail

The effect of pituitary removal on pain regulation in the rat.
MedLine Citation:
PMID:  7059807     Owner:  NLM     Status:  MEDLINE    
The effects of hypophysectomy (HX) on pain regulation in basal and in various stressful situations were investigated in the rat. Pain sensitivity was assessed by measuring the thresholds of 3 nociceptive reactions (tail withdrawal, vocalization, vocalization afterdischarge) following electrical stimulation of the tail. The completeness of HX and the integrity of hypothalamus were verified in each HX rat. (1) Baseline pain thresholds were lower in HX rats than in sham-operated animals; (2) naloxone (Nx) hyperalgesia was only slightly altered by HX; (3) different types of stress induced different types of changes in nociception i.e. analgesia or hyperalgesia. The influence of HX varied according to the stress: it increased hyperalgesia, reduced analgesia, or had no effect at all. These results indicate that in the rat: (i) the pituitary participates in the regulation of basal pain sensitivity, probably through analgesic factors; (ii) Nx hyperalgesia results essentially from an antagonism of endogenous opioids originating in the CNS and not in the pituitary; and (iii) the pain regulatory processes engaged in adaptation to stressful stimuli involve the CNS and the pituitary in variable proportions depending upon the nature of the stress.
C Vidal; J M Girault; J Jacob
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  233     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-05-12     Completed Date:  1982-05-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  53-64     Citation Subset:  IM    
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MeSH Terms
Differential Threshold
Electric Stimulation
Naloxone / pharmacology
Pain / drug therapy,  physiopathology*
Pituitary Gland / physiology*
Sodium Chloride / pharmacology
Stress, Physiological / physiopathology
Time Factors
Reg. No./Substance:
465-65-6/Naloxone; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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