| The effect of piribedil on body temperature in mice and rats. | |
| | |
MedLine Citation:
|
PMID: 600860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Piribedil produces a pronounced hypothermia both in mice and rats. This hypothermia was prevented by previous administration of dopamine receptor blocking agents (spiperone in mice and rats, pimozide in mice), tricyclic antidepressant drugs (imipramine, clomipramine, desipramine) in mice and LSD in rats. Administration of agents acting on serotonin receptors (cyproheptadine, p-chlorophenylalanine) or of a classical anticholinergic drug, atropine, did not change the hypothermizing effect of piribedil in rats. Thus, the hypothermia produced by piribedil is apparently similar to that produced by apomorphine. The possibility of a secondary stimulation of serotonergic receptors through direct stimulatory action of piribedil on dopamine neurons is discussed. |
| | |
Authors:
|
Z Kapturkiewicz; H Sowińska |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Polish journal of pharmacology and pharmacy Volume: 29 ISSN: 0301-0244 ISO Abbreviation: Pol J Pharmacol Pharm Publication Date: 1977 Nov-Dec |
Date Detail:
|
Created Date: 1978-03-21 Completed Date: 1978-03-21 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0366561 Medline TA: Pol J Pharmacol Pharm Country: POLAND |
Other Details:
|
Languages: eng Pagination: 609-18 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antidepressive Agents, Tricyclic / pharmacology Body Temperature / drug effects* Depression, Chemical Drug Interactions Female Male Mice Neurons / physiology Piperazines / pharmacology* Piribedil / pharmacology* Rats Receptors, Dopamine / drug effects Receptors, Muscarinic / drug effects Serotonin / physiology Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Antidepressive Agents, Tricyclic; 0/Piperazines; 0/Receptors, Dopamine; 0/Receptors, Muscarinic; 3605-01-4/Piribedil; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protective action of series of new mono-pyridinium salts and their effect on "aging" of acetylcholin...
Next Document: The relation between liver vitamin content and the duration of Schistosoma mansoni infection in mice...