Document Detail

The effect of physostigmine on (Na+ + K+)-ATPase activity in different rat brain regions.
MedLine Citation:
PMID:  6258966     Owner:  NLM     Status:  MEDLINE    
The activity of (Na+ + K+)-ATPase and acetylcholine esterase were followed in rat brain cerebral cortex, caudate, thalamus, hippocampus and medulla after i.v. administration of physostigmine. Both enzymes were found to be inhibited in a dose-dependent manner. The most pronounced inhibition of (Na+ + K+)-ATPase was found in caudate, where the highest activity of acetylcholine esterase is found.
T Stojanović; B M Djuricić; B B Mrsulja
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experientia     Volume:  36     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-05-21     Completed Date:  1981-05-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1348-50     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / pharmacology
Acetylcholinesterase / metabolism
Brain / enzymology*
Brain Mapping
Physostigmine / pharmacology*
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors,  metabolism*
Synaptic Membranes / enzymology
Reg. No./Substance:
51-84-3/Acetylcholine; 57-47-6/Physostigmine; EC; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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