Document Detail

The effect of physiological urine dilution on pregnancy test results in complicated early pregnancies.
MedLine Citation:
PMID:  9609277     Owner:  NLM     Status:  MEDLINE    
This study addresses the likelihood of false negative urine pregnancy test results, due to physiological urine dilution as described in some anecdotal reports. In this prospective study 320 pregnancy tests were performed on urine samples of varying concentrations obtained from 40 women, with suspected complications of early pregnancy, who had presented for ultrasound scans. Four different pregnancy tests were used and serum betahCG levels were measured quantitatively. Despite a mean fivefold increase in urine dilution, the pregnancy tests with low betahCG detection limits maintained maximal sensitivity. The detection of betahCG in dilute urine was adversely affected by using pregnancy tests with higher betahCG detection limits and these tests should be used with caution when assessing gynaecological emergencies.
A Ikomi; M Matthews; A M Kuan; G Henson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  105     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-18     Completed Date:  1998-06-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  462-5     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, Whittington Hospital, London, UK.
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MeSH Terms
Biological Markers / urine
Chorionic Gonadotropin, beta Subunit, Human / urine
False Negative Reactions
Osmolar Concentration
Pregnancy Complications / urine*
Pregnancy Tests / standards*
Prospective Studies
Sensitivity and Specificity
Urine / physiology
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human
Comment In:
Br J Obstet Gynaecol. 1999 Jan;106(1):87-8   [PMID:  10426268 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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