| The effect of physical conditioning on antipyrine clearance. | |
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MedLine Citation:
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PMID: 9459529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of physical conditioning on antipyrine clearance were studied in two groups of subjects. Healthy men not engaged in the systematic practice of any sport were compared with endurance runners (defined as men running > 80 km/week). Studies were carried out at three different periods of the annual plan training at 4-month intervals. Antipyrine was administered orally and pharmacokinetic parameters were obtained from saliva samples by the multiple-sample method. Endurance performance, expressed in terms of the maximal oxygen uptake (VO2max), the ventilatory threshold and the 4-mM x l(-1) lactate threshold (OBLA), was higher in trained than in control subjects at each of the three periods. Antipyrine clearance was also significantly elevated and antipyrine half-life reduced in runners during all periods. No significant difference in VO2max or antipyrine clearance was found between the various periods in either trained or control subjects. Both ventilatory threshold and OBLA increased significantly along the training period in conditioned subjects. Significant correlations were found between antipyrine clearance and VO2max, ventilatory threshold and OBLA. In summary, these results indicate an association between aerobic conditioning and increased hepatic oxidative metabolism of low-clearance drugs. |
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Authors:
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J G Villa; G Cuadrado; J E Bayón; J González-Gallego |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of applied physiology and occupational physiology Volume: 77 ISSN: 0301-5548 ISO Abbreviation: Eur J Appl Physiol Occup Physiol Publication Date: 1998 |
Date Detail:
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Created Date: 1998-03-06 Completed Date: 1998-03-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410266 Medline TA: Eur J Appl Physiol Occup Physiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 106-11 Citation Subset: IM |
Affiliation:
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Institute of Physical Education, University of León, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipyrine / analysis, pharmacokinetics* Body Composition Exercise / physiology* Heart Rate Humans Lactic Acid / blood Male Metabolic Clearance Rate Oxygen Consumption Physical Endurance / physiology* Running Saliva / chemistry |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid; 60-80-0/Antipyrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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