Document Detail

The effect of photochemotherapy on the cardiovascular system.
MedLine Citation:
PMID:  7240463     Owner:  NLM     Status:  MEDLINE    
Photochemotherapy, consisting of the oral administration of psoralens plus long-wave ultraviolet radiation (PUVA), involves standing in a warm light cabinet for a prolonged time. This study was done to evaluate the cardiovascular reactions in normal patients and in patients with cardiac disease receiving PUVA therapy. Of forty patients studied, six had cardiovascular disease and sixteen had essential hypertension. Holter monitoring during treatment revealed no significant arrhythmias. All patients had a modest increase in heart rate at the end of PUVA, with a mean increase of 22% of baseline. Blood pressure was not significantly changed, and 12-lead electrocardiograms done in twenty-two of the patients before and after PUVA showed no significant changes. Our patients, including those with cardiovascular disease and hypertension, tolerated the PUVA therapy without significant subjective reactions and without evidence of excessive cardiovascular stress.
S G Chappe; H H Roenigk; A J Miller; D E Beeaff; L Tyrpin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  4     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-08-10     Completed Date:  1981-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  561-6     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Cardiovascular Diseases / physiopathology*
Cardiovascular System*
Dizziness / etiology
Heart Rate
Middle Aged
PUVA Therapy / adverse effects*
Photochemotherapy / adverse effects*

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