Document Detail


The effect of phenobarbital and dexamethasone on hepatic cytochrome P-450 and alpha 1-acid glycoprotein in maternal and fetal guinea pigs.
MedLine Citation:
PMID:  2218069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of phenobarbital (PB) and dexamethasone (DX) on maternal and fetal hepatic cytochrome P450 content, benzphetamine (BzP) demethylation activity, the plasma concentration of alpha 1-acid glycoprotein (AGP), and the binding of propranolol (PPL) were examined in guinea pigs. In maternal guinea pigs, PB increased AGP-specific PPL binding by 131%, P450 by 94%, and BzP demethylation by 261%. DX only increased maternal AGP-specific PPL binding (122%). In fetal guinea pigs, neither PB nor DX resulted in significant increase for any of these parameters. The combination of PB and DX synergistically increased fetal P450 content (153% increase) and BzP demethylation (84% increase). In contrast, this combination treatment did not increase maternal P450 and BzP demethylation to a greater extent than by PB treatment alone nor did it increase the binding of PPL in PCA-treated fetal plasma. The synergy of P450 induction found in the fetus implicates glucocorticoids as important regulators of fetal hepatic microsomal enzyme maturation.
Authors:
M D Hill; F P Abramson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  69     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-11-19     Completed Date:  1990-11-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-48     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, George Washington University Medical Center, Washington, DC 20037.
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzo(a)pyrene / metabolism
Blood Proteins / metabolism
Cytochrome P-450 Enzyme System / metabolism*
Dealkylation
Dexamethasone / pharmacology*
Female
Fetus / metabolism*
Guinea Pigs
Hydrogen-Ion Concentration
Hysterectomy
Liver / enzymology*
Orosomucoid / metabolism*
Phenobarbital / pharmacology*
Pregnancy
Propranolol / blood
Protein Binding / drug effects
Grant Support
ID/Acronym/Agency:
GM 30529/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Orosomucoid; 50-02-2/Dexamethasone; 50-06-6/Phenobarbital; 50-32-8/Benzo(a)pyrene; 525-66-6/Propranolol; 9035-51-2/Cytochrome P-450 Enzyme System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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