| The effect of pharmacological treatment on ADMA in patients with heart failure. | |
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MedLine Citation:
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PMID: 21622137 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Asymmetric dimethylarginine (ADMA) plays a crucial role in the arginine-nitric oxide (NO) pathway. NO plays an important role in controlling vascular tone and regulates the contractile properties of cardiac myocytes. The purpose of this study was to investigate the effect of pharmacological treatment on asymmetrical dimethylarginine (ADMA) plasma levels in patients with acute congestive heart failure (HF). Patients with symptomatic acute congestive HF (NYHA Class III-IV) and impaired left ventricular (LV) function (ejection fraction less than 40 percent) were included in the study. ADMA and SDMA concentrations were assessed before and after pharmacological treatment in 18 critically ill patients on the intensive care unit by high performance liquid chromatography. All patients received a complete pharmacological treatment (diuretics, digoxin, ACE-inhibitors or angiotensin receptor blockers, and nitroglicerin) for the treatment of acute congestive HF. ADMA plasma levels of critically ill patients were significantly higher after pharmacological treatment respect baseline values (pre-treatment). In critically ill patients with acute congestive HF acute renal impairment function and the modulation of NOS determine plasma ADMA/SDMA levels after therapy. |
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Authors:
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Graziano Riccioni; Lorenza Speranza; Luca Scotti; Valentina Bucciarelli; Emanuela Di Ilio; Nicolantonio D'Orazio; Mirko Pesce; Antonio Aceto; Valeria Sorrenti; Alessandro Frigiola; Tonino Bucciarelli |
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Publication Detail:
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Type: Journal Article Date: 2011-06-01 |
Journal Detail:
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Title: Frontiers in bioscience (Elite edition) Volume: 3 ISSN: 1945-0508 ISO Abbreviation: Front Biosci (Elite Ed) Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485240 Medline TA: Front Biosci (Elite Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 1310-4 Citation Subset: IM |
Affiliation:
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Cardiology Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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