| The effect of permeation enhancers on the viscosity and the release profile of transdermal hydroxypropyl methylcellulose gel formulations containing diltiazem HCl. | |
| | |
MedLine Citation:
|
PMID: 20545504 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND AND METHOD: The objective of this study was to characterize the release of Diltiazem HCl (DTM HCl) from hydroxypropyl methylcellulose gels containing the following permeation enhancers at a 0.5% (w/w): sodium lauryl sulfate, dimethyl sulfoxide (DMSO), polysorbate 80, propylene glycol, N-methylpyrrolidone (NMP), fatty acids (oleic acid, caprylic acid, and myristic acid), and isopropyl myristate (IPM). The enhancers' effects on the gel's viscosity were also investigated. RESULTS: The novel findings of this study were the following: (i) polysorbate 80 was used for the first time as an enhancer with a hydrophilic compound in a hydrophilic carrier and it rendered the highest permeation flux (57.1 +/- 0.9 microg/cm(2)/h) compared with the rest of the enhancers, (ii) myristic acid (a 14-carbon-chain fatty acid) rendered the highest permeation flux (18.4 +/- 0.49 microg/cm(2)/h) among all fatty acids because of a decrease in the gel's viscosity, (iii) NMP (46.5 +/- 0.7 microg/cm(2)/h) and IPM (15.3 +/- 0.41 microg/cm(2)/h) increased the permeation flux from the second day onward. Both enhancers increased the gel's viscosity, (iv) sodium lauryl sulfate decreased the viscosity of the gel and the drug's permeation flux (8.1 +/- 0.21 microg/cm(2)/h) because of its binding with the drug, (v) propylene glycol decreased the permeation flux (10.2 +/- 0.32 microg/cm(2)/h) by increasing the gel viscosity, and (vi) DMSO increased the permeation flux (13.8 +/- 0.4 microg/cm(2)/h) without altering the viscosity. CONCLUSION: These findings indicate that to formulate DTM HCl into a hydroxypropyl methylcellulose gel the enhancers of choice should be polysorbate 80, myristic acid, DMSO, NMP, and IPM or combinations thereof. |
| | |
Authors:
|
Marianthi Karakatsani; Mahendra Dedhiya; Fotios M Plakogiannis |
Related Documents
:
|
1125234 - Isolation of five active thyrotropin components from human pituitary gland. 14934 - Spontaneous deamidation of a protein antibiotic, neocarzinostatin, at weakly acidic ph.... 6603434 - Effects of ionizing radiation on nitric oxide myoglobin. part 2. effects on the globin ... 8931254 - Isolation and partial characterization of a polypeptide from phoneutria nigriventer spi... 637914 - Comparative studies of porphyrin production in propionibacterium acnes and propionibact... 9777704 - On the helical conformation of un-ionized poly(gamma-d-glutamic acid). |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Drug development and industrial pharmacy Volume: 36 ISSN: 1520-5762 ISO Abbreviation: Drug Dev Ind Pharm Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-07 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7802620 Medline TA: Drug Dev Ind Pharm Country: England |
Other Details:
|
Languages: eng Pagination: 1195-206 Citation Subset: IM |
Affiliation:
|
Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA. marianthi_g_karakatsani@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vitro and in vivo evaluation of levofloxacin sustained-release capsules.
Next Document: Controlled release formulation of ranitidine-containing montmorillonite and Eudragit E-100.