| The effect of peritoneal lavage with tetracycline solution on postoperative infection. A prospective, randomized, clinical trial. | |
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MedLine Citation:
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PMID: 3510839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prospective randomized trial was performed to determine the value of tetracycline lavage in addition to systemic antibiotic prophylaxis in 159 patients undergoing elective and emergency intestinal operations. Tetracycline lavage was associated with a significant overall reduction in postoperative infection rates in 25 of 74 patients (34 percent) receiving saline lavage compared with 15 of 85 patients (18 percent) having tetracycline lavage (P less than 0.05). Tetracycline lavage was associated with a significant reduction in the counts of aerobic and anaerobic bacteria in the peritoneal fluid at the end of the operation (P less than 0.05 and P less than 0.01, respectively) and with a significant reduction of aerobes 24 hours postoperatively (P less than 0.02). Tetracycline lavage would appear to confer clinical benefit in preventing postoperative infection. |
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Authors:
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S H Silverman; N S Ambrose; D J Youngs; A F Shepherd; A P Roberts; M R Keighley |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Diseases of the colon and rectum Volume: 29 ISSN: 0012-3706 ISO Abbreviation: Dis. Colon Rectum Publication Date: 1986 Mar |
Date Detail:
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Created Date: 1986-03-24 Completed Date: 1986-03-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372764 Medline TA: Dis Colon Rectum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 165-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Bacterial Infections / prevention & control* Clinical Trials as Topic Colonic Diseases / surgery Female Humans Intestinal Diseases / surgery Irrigation Male Middle Aged Prospective Studies Random Allocation Sodium Chloride Surgical Wound Infection / prevention & control* Tetracycline / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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60-54-8/Tetracycline; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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