Document Detail

The effect of a peripheral decarboxylase inhibitor (carbidopa) on monoamine and neuroendocrine function in man.
MedLine Citation:
PMID:  558549     Owner:  NLM     Status:  MEDLINE    
Carbidopa, a selective extracerebral decarboxylase inhibitor, was given to 10 normal volunteers to determine its effects on endogenous catecholamine, indoleamine, and endocrine function. Tryptamine, which is largely extracerebral in origin, was inhibited markedly (80 percent) by the carbidopa; 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenolglycol (MHPG) excretion also were inhibited by the drug but not to the same degree as tryptamine. These differential results may be due partly to the higher central nervous system origin of the 5-HIAA and MHPG but also to a peripheral "stores" effect. In addition, carbidopa resulted in significant increases in plasma prolactin and a small but significant decrease in plasma glucagon.
P E Garfinkel; J J Warsh; H C Stancer; D D Godse; G M Brown; M Vranic
Related Documents :
22540429 - Serum levels of adam12-s: possible association with the initiation and progression of d...
1967909 - Plasma amino acid kinetics during acute states of glucagon deficiency and excess in hea...
3947899 - Role of catabolic hormones in the hypoketonaemia of injury.
3993789 - Postprandial regulation of renal hemodynamics: role of pancreatic glucagon.
7177779 - Effect of cold ambient temperature on glucose and alanine turnover in dogs.
247999 - Signals for glucagon secretion.
213519 - Evaluation of a radioimmunoassay for plasma adrenocorticotrophin.
15795649 - Do thyroxine and thyroid-stimulating hormone levels reflect urinary iodine concentrations?
9038779 - Gonadotrope responsiveness in orchidectomized sheep: effect of duration of a simulated ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  27     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  443-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carbidopa / pharmacology*
Carboxy-Lyases / antagonists & inhibitors*
Glycols / metabolism*
Hydrazines / pharmacology*
Hydroxyindoleacetic Acid / metabolism*,  urine
Methoxyhydroxyphenylglycol / metabolism*,  urine
Middle Aged
Prolactin / metabolism
Tryptamines / metabolism*,  urine
Reg. No./Substance:
0/Glycols; 0/Hydrazines; 0/Tryptamines; 38821-49-7/Carbidopa; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; 9002-62-4/Prolactin; EC 4.1.1.-/Carboxy-Lyases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison between the effects of pindolol and propranolol on essential tremor.
Next Document:  The in vivo development of plasma cells: a morphologic study of human cerebrospinal fluid.