Document Detail

The effect of a peripheral decarboxylase inhibitor (carbidopa) on monoamine and neuroendocrine function in man.
MedLine Citation:
PMID:  558549     Owner:  NLM     Status:  MEDLINE    
Carbidopa, a selective extracerebral decarboxylase inhibitor, was given to 10 normal volunteers to determine its effects on endogenous catecholamine, indoleamine, and endocrine function. Tryptamine, which is largely extracerebral in origin, was inhibited markedly (80 percent) by the carbidopa; 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenolglycol (MHPG) excretion also were inhibited by the drug but not to the same degree as tryptamine. These differential results may be due partly to the higher central nervous system origin of the 5-HIAA and MHPG but also to a peripheral "stores" effect. In addition, carbidopa resulted in significant increases in plasma prolactin and a small but significant decrease in plasma glucagon.
P E Garfinkel; J J Warsh; H C Stancer; D D Godse; G M Brown; M Vranic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  27     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  443-7     Citation Subset:  IM    
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MeSH Terms
Carbidopa / pharmacology*
Carboxy-Lyases / antagonists & inhibitors*
Glycols / metabolism*
Hydrazines / pharmacology*
Hydroxyindoleacetic Acid / metabolism*,  urine
Methoxyhydroxyphenylglycol / metabolism*,  urine
Middle Aged
Prolactin / metabolism
Tryptamines / metabolism*,  urine
Reg. No./Substance:
0/Glycols; 0/Hydrazines; 0/Tryptamines; 38821-49-7/Carbidopa; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; 9002-62-4/Prolactin; EC 4.1.1.-/Carboxy-Lyases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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