Document Detail


The effect of a peripheral decarboxylase inhibitor (carbidopa) on monoamine and neuroendocrine function in man.
MedLine Citation:
PMID:  558549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carbidopa, a selective extracerebral decarboxylase inhibitor, was given to 10 normal volunteers to determine its effects on endogenous catecholamine, indoleamine, and endocrine function. Tryptamine, which is largely extracerebral in origin, was inhibited markedly (80 percent) by the carbidopa; 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenolglycol (MHPG) excretion also were inhibited by the drug but not to the same degree as tryptamine. These differential results may be due partly to the higher central nervous system origin of the 5-HIAA and MHPG but also to a peripheral "stores" effect. In addition, carbidopa resulted in significant increases in plasma prolactin and a small but significant decrease in plasma glucagon.
Authors:
P E Garfinkel; J J Warsh; H C Stancer; D D Godse; G M Brown; M Vranic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  27     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  443-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Carbidopa / pharmacology*
Carboxy-Lyases / antagonists & inhibitors*
Female
Glycols / metabolism*
Humans
Hydrazines / pharmacology*
Hydroxyindoleacetic Acid / metabolism*,  urine
Male
Methoxyhydroxyphenylglycol / metabolism*,  urine
Middle Aged
Prolactin / metabolism
Tryptamines / metabolism*,  urine
Chemical
Reg. No./Substance:
0/Glycols; 0/Hydrazines; 0/Tryptamines; 38821-49-7/Carbidopa; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; 9002-62-4/Prolactin; EC 4.1.1.-/Carboxy-Lyases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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