Document Detail

The effect of perioperative exogenous growth hormone on wound bursting strength in normal and malnourished rats.
MedLine Citation:
PMID:  2299548     Owner:  NLM     Status:  MEDLINE    
Patients with significant malnutrition secondary to underlying disease may require major surgical intervention on an urgent basis. Nutritional restoration using enteral or intravenous alimentation requires a delay of 10 to 14 days and is frequently not practical. With the availability of human growth hormone (GH) produced by recombinant DNA technology, this study was undertaken to evaluate the effect of exogenous GH on wound tensile strength in a rat model. Fifty-four animals were divided into three groups: group I, normal nourished control; group II, malnourished; group III, malnourished, rat GH treated (1 mg GH administered 3 days preoperative and 5 days postoperative celiotomy). Wound tensile strength was measured at 6 days postoperatively. Wound strengths in malnourished rats were significantly less than in normal controls (P less than .001). With the administration of growth hormone in group III, wound strength was significantly improved when slightly improved over normally nourished controls (P less than .05). A dose response curve demonstrated progressive improvement in wound tensile strength from 0.01 mg/d to 1.0 mg/d. Thus growth hormone administration to malnourished animals significantly enhances wound strength. With the availability of recombinant produced human GH these observations may be clinically applicable.
Y Zaizen; E G Ford; G Costin; J B Atkinson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  25     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-03-15     Completed Date:  1990-03-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  70-4     Citation Subset:  IM    
Division of Pediatric Surgery, Childrens Hospital, Los Angeles, CA 90027.
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MeSH Terms
Abdominal Injuries / physiopathology
Growth Hormone / administration & dosage,  pharmacology*
Intraoperative Care*
Nutrition Disorders / physiopathology*
Rats, Inbred Strains
Tensile Strength / drug effects
Wound Healing / drug effects*
Reg. No./Substance:
9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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