| The effect of periodontal treatment on IL-6 production of peripheral blood monocytes in aggressive periodontitis and chronic periodontitis patients. | |
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MedLine Citation:
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PMID: 18523355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Several cytokines, including IL-6 have been implicated in the pathogenesis of periodontal disease. It is established that monocytes from periodontitis subjects show an increased production of IL-6 as compared to healthy subjects. However, little is known about the effect of periodontal treatment on IL-6 production by monocytes in subsets of periodontitis patients. OBJECTIVE: The aim of the present study was to evaluate the effect of surgical periodontal treatment on IL-6 production of peripheral blood monocytes (PBM) in aggressive periodontitis patients (AP) and chronic periodontitis patients (CP) before and after stimulation by E.coli LPS. METHODS: Fifteen AP patients, 15 CP patients and 15 periodontally healthy subjects (PH) took part in the study. PBM IL-6 pro-duction was measured, using ELISA, before and after stimulation of cultured PBM cells by 0.1 microg/ml LPS of E.coli. Following full-mouth non-surgical and surgical periodontal treatment of the AP and CP groups, the same measurements were repeated for these two groups. RESULTS: LPS-stimulated IL-6 production was significantly greater than non-stimulated IL-6 for all 3 groups. Before periodontal treatment, LPS-stimulated IL-6 pro-duction of the AP group was significantly greater than the other 2 groups. Periodontal treatment did not result in a significant decrease in unstimulated or LPS-stimulated IL-6 production by PBM cells in AP and CP patients. No correlation was detected between IL-6 levels and baseline clinical parameters or changes in clinical parameters. CONCLUSION: PBM cells in AP patients might be hyper-responsive in terms of IL-6 production. This hyper-responsiveness does not seem to return to that of healthy subjects even after a successful periodontal treatment. Moreover, the regulation of host inflammatory mechanisms upon LPS challenge might be different between AP and CP patients. |
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Authors:
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Mehrdad Radvar; Jalil Tavakkol-Afshari; Mahboobeh N Bajestan; Mohammad-Reza Naseh; Hamid-Reza Arab |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Iranian journal of immunology : IJI Volume: 5 ISSN: 1735-1383 ISO Abbreviation: Iran J Immunol Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-04 Completed Date: 2009-02-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101282932 Medline TA: Iran J Immunol Country: Iran |
Other Details:
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Languages: eng Pagination: 100-6 Citation Subset: IM |
Affiliation:
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Department of Periodontology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran. radvarm@mums.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cells, Cultured Chronic Disease Female Humans Interleukin-6 / biosynthesis*, immunology* Male Monocytes / immunology*, metabolism* Periodontitis / blood*, immunology*, pathology, therapy |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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