Document Detail

The effect of percutaneous transluminal coronary angioplasty on anaerobic threshold in patients with angina pectoris.
MedLine Citation:
PMID:  1343627     Owner:  NLM     Status:  MEDLINE    
The anaerobic threshold (AT) is regarded an objective parameter for evaluating exercise tolerance, but its relationship to the improvement of myocardial ischemia remains uncertain. To investigate this relationship, submaximal treadmill exercise tests were performed for 15 consecutive patients with angina pectoris who had undergone successful percutaneous transluminal coronary angioplasty (PTCA). Before and after PTCA, the AT was determined using cardiorespiratory monitoring, while the patients were receiving their usual vasodilator medications. 1) Before PTCA, the minute oxygen uptake (VO2) at the AT correlated well with the peak VO2 (r = 0.92, p < 0.002). The VO2 at the AT, however, showed less correlation (r = 0.71, p < 0.002) with the VO2 at ST segment depression, while the latter parameter correlated closely with the peak VO2 (r = 0.91, p < 0.002). 2) After PTCA, exercise time, peak VO2, and the double product at peak exercise increased significantly (from 640.1 +/- 212.2 to 772.9 +/- 230.0 sec, p < 0.001, from 19.1 +/- 5.2 to 22.4 +/- 4.9 ml/min/kg, p < 0.05, and from 19.7 +/- 5.0 x 10(3) to 23.7 +/- 4.5 x 10(3), p < 0.001, respectively). However, the VO2 at the AT did not increase significantly (from 15.8 +/- 4.1 to 16.6 +/- 3.5 ml/min/kg, p = NS). The heart rate, systolic blood pressure, and double product at the AT did not change significantly. In conclusion, in patients with angina pectoris, the AT is apparently related to the onset of myocardial ischemia. However, the AT does not necessarily reflect acute improvement of myocardial ischemia immediately after PTCA.
K Ohnishi; Y Kohno; K Furukawa; S Terashima; K Matsubara; K Kawata; T Nakamura; A Azuma; H Katsume; M Nakagawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiology     Volume:  22     ISSN:  0914-5087     ISO Abbreviation:  J Cardiol     Publication Date:  1992  
Date Detail:
Created Date:  1994-03-11     Completed Date:  1994-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  617-24     Citation Subset:  IM    
Second Department of Medicine, Kyoto Prefectural University of Medicine.
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MeSH Terms
Anaerobic Threshold*
Angina Pectoris / physiopathology,  therapy*
Angioplasty, Transluminal, Percutaneous Coronary*
Blood Pressure
Exercise Test
Exercise Tolerance
Heart Rate
Middle Aged
Oxygen Consumption

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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