Document Detail


The effect of pentoxifylline on cochlear blood flow.
MedLine Citation:
PMID:  1734376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pentoxifylline, a phosphodiesterase inhibitor and hemorrheologic agent has been found to increase oxygen delivery to ischemic tissue. Intravenous pentoxifylline was administered to normal guinea pigs in order to assess the effect of pentoxifylline on cochlear blood flow and to elucidate its mechanism of action. Intravenous pentoxifylline was found to acutely increase cochlear blood flow in a dose-dependent manner. In normal animals, the effect appeared strongly related to the rheologic properties of this agent rather than a vasodilative action. Normovolemic hemodilution with 75% dextran resulted in no increase in cochlear blood flow during infusion of pentoxifylline, whereas the application of nitroprusside over the round window failed to abolish the effect of pentoxifylline.
Authors:
M J LaRouere; J S Sillman; M T Tsai; A L Nuttall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  106     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-04     Completed Date:  1992-03-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
Affiliation:
Michigan Ear Institute, Farmington Hills 48334.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Carbon Dioxide / blood
Cochlea / blood supply*
Dose-Response Relationship, Drug
Female
Guinea Pigs
Hematocrit
Hemodilution
Male
Oxygen / blood
Pentoxifylline / pharmacology*
Regional Blood Flow / drug effects
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 6493-05-6/Pentoxifylline; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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