Document Detail


The effect of pentagastrin, cholecystokinin and their analogues on rat arterial blood pressure and isolated heart.
MedLine Citation:
PMID:  9020529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of pentagastrin (PG) and its analogues: 3-leupentagastrin (3-leu-PG), 4-AspOBzl-pentagastrin (4-AspOBzl-PG), and of the cholecystokinin -terminal tetrapeptide (CCK-4) and its analogue CCK-4(Phet) on rat arterial blood pressure and isolated heart were studied. 4-AspOBzl-PG and CCK-4 (Phet) had no effect on the arterial blood pressure or the isolated heart. PG (1.0 microgram/kg iv), slightly raised the systolic and diastolic arterial blood pressure, whereas 3-leu-PG (1.0 microgram/kg iv) slightly lowered the systolic arterial blood pressure. 3-leu-PG (0.1 microgram/0.1 ml), like PG (0.1 microgram/ 0.1 ml) increased the contraction amplitude of the isolated heart and had no effect on the heart rate, but unlike PG, it had no effect on coronary outflow. CCK-4 (1.0 microgram/kg iv) slightly raised the systolic arterial blood pressure but, unlike cholecystokinin had no effect on the isolated heart. We conclude that shortening of the CCK chain to a C-terminal tetrapeptide reduces the positive inotropic effect. Blocking of one of the aspartic acid carboxyl groups by a benzyl radical in the 4 PG position eliminates the PG effect on the circulatory system. Substitution of metionine for leucine at the 3-PG position reduces the PG action on the circulatory system.
Authors:
R Wiśniewska; K Wiśniewski
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Roczniki Akademii Medycznej w Białymstoku (1995)     Volume:  41     ISSN:  -     ISO Abbreviation:  Rocz. Akad. Med. Bialymst.     Publication Date:  1996  
Date Detail:
Created Date:  1997-03-06     Completed Date:  1997-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9515551     Medline TA:  Rocz Akad Med Bialymst     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  183-90     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Medical Academy of Białystok.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Cholecystokinin / pharmacology*
Coronary Circulation / drug effects*
Injections, Intravenous
Male
Myocardial Contraction / drug effects*
Pentagastrin / pharmacology*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
5534-95-2/Pentagastrin; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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