Document Detail

The effect of peep-ventilation on cardiac function in closed chest pigs.
MedLine Citation:
PMID:  7716829     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Does ventilation with positive end-expiratory pressure (PEEP) depress myocardial contractility? DESIGN: Ten piglets were anaesthetized and prepared for the measurement of cardiac output (SV) and right (MRAPtm) and left (MLAPtm) mean transmural atrial pressure, the latter serving as indices of preload. 500 ml of autologous blood was re-transfused during intermittent positive pressure ventilation without PEEP (IPPV) and continuous positive pressure ventilation with 15 cm H2O PEEP (CPPV). MEASUREMENTS AND RESULTS: Right and left ventricular function curves were drawn by plotting MRAPtm and MLAPtm respectively versus the corresponding strokevolumes before and after re-transfusion. Similar inclinations were obtained during IPPV and CPPV on either side of the heart. CONCLUSIONS: Although the ventricular function curves during IPPV and CPPV covered partially different preload levels, the results suggest that CPPV i.e. PEEP does not affect myocardial contractility.
J E Berglund; E Haldén; S Jakobson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Upsala journal of medical sciences     Volume:  99     ISSN:  0300-9734     ISO Abbreviation:  Ups. J. Med. Sci.     Publication Date:  1994  
Date Detail:
Created Date:  1995-05-17     Completed Date:  1995-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0332203     Medline TA:  Ups J Med Sci     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  167-78     Citation Subset:  IM    
Department of Anaesthesiology and Intensive Care, University Hospital, Uppsala, Sweden.
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MeSH Terms
Blood Pressure
Heart Rate
Myocardial Contraction*
Positive-Pressure Respiration*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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