Document Detail


The effect of parental and maternal-fetal histocompatibility at MHC on sex ratio in offspring.
MedLine Citation:
PMID:  2371714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The secondary sex ratio (male births of total births) variation was investigated as a function of MHC antigens. Previous studies have indicated that at conception male zygotes are more frequent than female ones and abortions of male fetuses prevail. The present investigation addresses the question whether the histocompatibility relationships either between parents or between mother and offsprings may favor or hinder the outcome of pregnancy: particular combinations may cause distortions in the sex ratio. The results of the analysis of a sample of fertile families, demonstrate that, in first parities, female births are favored when parents share antigens at both HLA-A and -B loci (S.R. = 0.389), and mothers and fetuses share antigens at the HLA-B locus (S.R. = 0.222). The lack of antigens shared by parents at the three loci HLA-A, -B and -DR increases first male births (S.R. = 0.696). In the case of fetal maternal histocompatibility at DR locus only a slight, non-significant, increase in male first births (S.R. = 0.667) was observed. The effect of histocompatibility at HLA-B locus alone requires further investigation in order to assess the possible selective effect against male histocompatible embryos.
Authors:
P Astolfi; M Martinetti; F Gigli-Berzolari; M Cuccia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tissue antigens     Volume:  35     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-08-17     Completed Date:  1990-08-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  172-7     Citation Subset:  IM    
Affiliation:
Department of Genetics and Microbiology, University of Pavia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Embryo, Mammalian / immunology
Female
HLA Antigens / genetics,  immunology*
HLA-A Antigens / genetics,  immunology
HLA-B Antigens / genetics,  immunology
HLA-DR Antigens / genetics,  immunology
Humans
Immunity, Maternally-Acquired*
Major Histocompatibility Complex / immunology*
Male
Paternity*
Pregnancy
Sex Ratio*
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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