Document Detail

The effect of para-nonylphenol on Japanese eel (Anguilla japonica) spermatogenesis in vitro.
MedLine Citation:
PMID:  15642638     Owner:  NLM     Status:  MEDLINE    
Endocrine disrupters have been recognized to interfere with endocrine systems that regulate reproduction, for example, by mimicking or inhibiting the action of endogenous sex steroid hormones including estradiol-17beta (E2). In the present study, we examined the effect of an endocrine disrupter, para-nonylphenol (p-NP) on spermatogenesis, and compared it with the action of E2, using an eel testicular organ culture system. p-NP alone stimulated early spermatogonial renewal in the same manner as E2. Neither induced further progress in spermatogenesis. In the presence of 11-ketotestosterone (11-KT), the major androgen in teleosts, p-NP did not prevent the 11-KT-induced progress in spermatogenesis. However, this treatment enlarged the Sertoli cells. Electron microscopic observation revealed that enlarged Sertoli cells contained well-developed organelles. Moreover, the proportion of germ cells appeared to have decreased as a result of Sertoli cell hypertrophy. These results clearly show that p-NP has an effect on Sertoli cells in the presence of an androgen (11-KT), potentially disturbing 11-KT-induced spermatogenesis.
C Miura; N Takahashi; F Michino; T Miura
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-12-16
Journal Detail:
Title:  Aquatic toxicology (Amsterdam, Netherlands)     Volume:  71     ISSN:  0166-445X     ISO Abbreviation:  Aquat. Toxicol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-11     Completed Date:  2005-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500246     Medline TA:  Aquat Toxicol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  133-41     Citation Subset:  IM    
Laboratory of Fish Reproductive Physiology, Faculty of Agriculture, Ehime University, Matsuyama, Ehime 790-8566, Japan.
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MeSH Terms
Analysis of Variance
Anguilla / metabolism*
Apoptosis / drug effects
Estradiol / toxicity
In Situ Nick-End Labeling
Microscopy, Electron
Phenols / toxicity*
Sertoli Cells / drug effects,  ultrastructure
Spermatogenesis / drug effects*
Testosterone / analogs & derivatives*
Reg. No./Substance:
0/Phenols; 104-40-5/4-nonylphenol; 50-28-2/Estradiol; 53187-98-7/11-ketotestosterone; 58-22-0/Testosterone; 59-14-3/Bromodeoxyuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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