| The effect of para-aminobenzoic acid and taurocholic acid feeding on human bile composition. | |
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MedLine Citation:
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PMID: 300905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven patients were investigated after cholecystectomy and exploration of the common bile duct to determine bile composition and excretion rates. An initial depression of the major components of bile stabilized by the sixth postoperative day. Feeding of para-aminobenzoic acid and taurocholic acid to these patients demonstrated an increase in excretion of total bile acids, taurine and glycine conjugates, cholates and deoxycholates. Para-aminobenzoic acid in the doses used failed to block glycine conjugation. Preferential conjugation of bile acid with glycine is due to a deficient taurine pool and not a preferential metabolic pathway. |
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Authors:
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B Gardner; C Dennis; J Patti; M Chenouda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgery, gynecology & obstetrics Volume: 144 ISSN: 0039-6087 ISO Abbreviation: Surg Gynecol Obstet Publication Date: 1977 Jun |
Date Detail:
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Created Date: 1977-06-30 Completed Date: 1977-06-30 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0101370 Medline TA: Surg Gynecol Obstet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 879-82 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Aminobenzoic Acid
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pharmacology* Administration, Oral Aminobenzoic Acids / pharmacology* Bile / analysis, drug effects*, metabolism Bile Acids and Salts / metabolism Cholecystectomy Cholesterol / metabolism Glycine / metabolism Humans Phosphatidylcholines / metabolism Taurocholic Acid / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Aminobenzoic Acids; 0/Bile Acids and Salts; 0/Phosphatidylcholines; 150-13-0/4-Aminobenzoic Acid; 56-40-6/Glycine; 57-88-5/Cholesterol; 81-24-3/Taurocholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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