Document Detail

The effect of pancreatic polypeptide and peptide YY on pancreatic blood flow and pancreatic exocrine secretion in the anesthetized dog.
MedLine Citation:
PMID:  1994383     Owner:  NLM     Status:  MEDLINE    
Pancreatic polypeptide (PP) and peptide YY (PYY) are inhibitors of pancreatic exocrine secretion in vivo but not in vitro, which suggests intermediate mechanisms of action. To examine the role of pancreatic blood flow in these inhibitory effects, xenon-133 gas clearance was used to measure pancreatic blood flow while simultaneously measuring pancreatic exocrine secretion. PP or PYY (400 pmol/kg/h) was administered during the intermediate hour of a 3-h secretin (125 ng/kg/h)/cholecystokinin octapeptide (CCK-8) (50 ng/kg/h) infusion. Exocrine secretion and pancreatic blood flow during the PP or PYY hours were compared with that observed in the first and third hours of the secretin/CCK-8 infusion. PP and PYY significantly inhibited secretin/CCK-8-induced pancreatic exocrine secretion. In addition, PYY (but not PP) significantly reduced pancreatic blood flow during secretin/CCK-8 stimulation. Nevertheless, there was no correlation between pancreatic blood flow and bicarbonate or protein outputs. It is concluded that changes in pancreatic blood flow do not mediate the inhibitory effects of PP or PYY on the exocrine pancreas.
A R DeMar; R Lake; A S Fink
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pancreas     Volume:  6     ISSN:  0885-3177     ISO Abbreviation:  Pancreas     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-03-21     Completed Date:  1991-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  IM    
Department of Surgery, Cincinnati VAMC, Ohio.
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MeSH Terms
Bicarbonates / metabolism
Pancreas / blood supply*,  drug effects,  secretion
Pancreatic Polypeptide / pharmacology*
Peptide YY
Peptides / pharmacology*
Proteins / secretion
Regional Blood Flow / drug effects
Secretin / pharmacology
Sincalide / pharmacology
Xenon Radioisotopes
Reg. No./Substance:
0/Bicarbonates; 0/Peptides; 0/Proteins; 0/Xenon Radioisotopes; 106388-42-5/Peptide YY; 1393-25-5/Secretin; 25126-32-3/Sincalide; 59763-91-6/Pancreatic Polypeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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