Document Detail

The effect of p22(phox) -930A/G, A640G and C242T polymorphisms of NADPH oxidase on peripheral and central pressures in healthy, normotensive individuals.
MedLine Citation:
PMID:  20505675     Owner:  NLM     Status:  In-Process    
The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase produces superoxide, thus regulating redox state in the vessel wall. Three single-nucleotide polymorphisms (SNPs; -930A/G, A640G and C242T) of the p22(phox) subunit have been associated with hypertension; however, their role in peripheral and central pressures in normotensive individuals has not been addressed. A total of 210 healthy, normotensive individuals were studied. Genotypes for the -930A/G, A640G and C242T polymorphisms were determined by polymerase chain reaction. Peripheral pressures were measured by mercury sphygmomanometer and aortic pressures by a validated device using applanation tonometry. Both peripheral and central pressures differed across -930A/G genotypes. G allele carriers showed higher levels of peripheral systolic blood pressure (PSBP; AA: 113+/-12, GG/AG: 119+/-12 mm Hg; P<0.01) and peripheral diastolic blood pressure (AA: 70+/-9, GG/AG: 73+/-10 mm Hg; P<0.05). Regarding central pressures, AA homozygotes had lower central systolic blood pressure (CSBP; AA: 103+/-12, GG/AG: 108+/-12 mm Hg; P<0.01) and central diastolic blood pressure (AA: 71+/-9, GG/AG: 74+/-10 mm Hg; P<0.05). In multiple linear regression analysis, presence of the G allele (AG or GG) independently predicted CSBP. Blood pressure levels did not differ across A640G and C242T genotypes. The -930A/G polymorphism of p22(phox) is a determinant of peripheral and central pressures in normotensive individuals. The G allele is associated with higher blood pressure in the brachial artery, as well as in the aorta. These findings further elucidate the role of this polymorphism in the regulation of blood pressure. In contrast, the A640G and C242T SNPs do not influence peripheral and central pressures in normotensives.
Panagiotis Xaplanteris; Charalambos Vlachopoulos; Katerina Baou; Carmen Vassiliadou; Ioanna Dima; Nikolaos Ioakeimidis; Christodoulos Stefanadis
Related Documents :
15019285 - Association between the interleukin-1beta c(-511)t polymorphism and blood pressure in a...
17701555 - Multiple strategies for o2 transport: from simplicity to complexity.
11775125 - G protein beta3 subunit gene 825t allele is associated with increased left ventricular ...
12719445 - Heritability of blood pressure and hemodynamics in african- and european-american youth.
12234955 - Serotonin reuptake inhibitor (paxil) does not prevent the vasovagal reaction associated...
25348555 - Epidural anesthesia in capuchin monkeys (sapajus libidinosus).
Publication Detail:
Type:  Journal Article     Date:  2010-05-27
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  33     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  814-8     Citation Subset:  IM    
1st Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Comment In:
Hypertens Res. 2010 Aug;33(8):786-7   [PMID:  20613760 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Differential effects of candesartan and olmesartan on adipose tissue activity biomarkers in type II ...
Next Document:  Medical expenditures of men with hypertension and/or a smoking habit: a 10-year follow-up study of N...