Document Detail

The effect of oxazepam on ocular readaptation time.
MedLine Citation:
PMID:  419971     Owner:  NLM     Status:  MEDLINE    
The readaptation time (RAT) is the interval during which a person exposed to a bright intense light flash cannot perceive a given target. In this study the target used was an optokinetic pattern and the elicited nystagmus (OKN) was registered with electrooculography (EOG), thus giving an objective registration of RAT. Oxazepam in therapeutic doses was given to five healthy subjects and the RAT and serum concentrations of the drug were registered simultaneously at different time intervals. An almost parallel increase of RAT and serum concentration of oxazepam was recorded. This suggests that RAT reflects the depressant effect on the CNS of this drug and it may be used as an objective method of following the clinical effect of a depressant drug as a function of time after intake.
H Bergman; S Borg; B Högman; H Larsson; C J Linde; B Tengroth
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta ophthalmologica     Volume:  57     ISSN:  0001-639X     ISO Abbreviation:  Acta Ophthalmol (Copenh)     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370347     Medline TA:  Acta Ophthalmol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
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MeSH Terms
Adaptation, Ocular / drug effects*
Eye Movements / drug effects
Oxazepam / blood,  pharmacology*
Photic Stimulation
Reg. No./Substance:

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