Document Detail

The effect of organ of corti loss on ganglion cell survival in humans.
MedLine Citation:
PMID:  16885783     Owner:  NLM     Status:  MEDLINE    
HYPOTHESIS: Severe spiral ganglion cell loss does not necessarily follow loss of hair cells or supporting cells in humans. BACKGROUND: Despite some publications to the contrary, statements that loss of hair cells and/or supporting cells of the organ of Corti results in a severe loss of spiral ganglion cells in humans still appear in the literature, especially in respect to cochlear implants. This assumption is apparently based on studies in animals or cell culture and not from studies of human temporal bones. METHODS: Morphological analysis of archival temporal bones with microscopic and statistical analysis of ganglion cell, hair cell, and supporting cell populations was performed in 33 ears with total hearing losses of varying causes and durations of deafness. None of the ears had remaining hair cells. Six ears had had cochlear implants. RESULTS: Ganglion cell counts ranging from 2,889 to 34,299 and the corresponding percentage of remaining ganglion cells based on age-normative data were not significantly related to the duration of hearing loss (r = -0.13 and 0.02, respectively, p > 0.05) or to remaining supporting cell populations (r's from 0.15 to 0.27, p > 0.05). More than half of ears (51.5%) had ganglion cell counts within two standard deviations of age-normative means. Mean ganglion cell counts and percentage of remaining ganglion cells of ears with surviving peripheral processes (dendrites) did not differ significantly from those of ears with no peripheral processes. CONCLUSION: The loss of hair and supporting cells in the organ of Corti in humans does not necessarily result in as significant a loss of spiral ganglion cells as has been reported animals. In fact, our results suggest that ganglion cell loss may be a primary concomitant loss due to the disease process.
Karen Borne Teufert; Fred H Linthicum; Sarah S Connell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology     Volume:  27     ISSN:  1531-7129     ISO Abbreviation:  Otol. Neurotol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-28     Completed Date:  2008-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100961504     Medline TA:  Otol Neurotol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1146-51     Citation Subset:  IM    
Histopathology Department, House Ear Institute, Los Angeles, California 90057, USA.
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MeSH Terms
Aged, 80 and over
Cell Count
Cell Survival
Cochlear Implants
Hearing Loss / pathology*
Middle Aged
Organ of Corti / pathology*
Spiral Ganglion / pathology*

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