| The effect of orally and vaginally administered misoprostol on inflammatory mediators and cervical ripening during early pregnancy. | |
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MedLine Citation:
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PMID: 15964290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The objective of the present study was to investigate the effect of vaginally and orally administered misoprostol on the local cervical inflammatory response. METHODS: Healthy women with a normal intrauterine pregnancy between 8 and 12 weeks of gestation presenting for an elective termination of pregnancy by vacuum aspiration were recruited into a cohort study with a control and a treatment group. In the treatment group, the women were randomized to misoprostol, 400 mug, given either orally or vaginally 3 h before surgery. Immunohistochemistry staining of CD45, CD68, MMP 8, MMP 9, TIMP 1 and TIMP 2 were assessed in cervical biopsies obtained directly prior to mechanical cervical dilatation and vacuum aspiration. RESULTS: In the treatment group, there was a greater amount of CD45-positive cells in the subepithelium region of the cervix compared to the control group. The staining of CD68 was similar in both groups. The immunostaining of MMP 8 and MMP 9 was greater in the treatment group, while the expression of TIMP 1 and TIMP 2 did not differ between control and treatment groups. CONCLUSIONS: Compared to untreated controls, treatment with misoprostol was associated with a greater expression of inflammatory cells. It could be hypothesized that administration of misoprostol mimics the cervical ripening at term pregnancy by a possible influx and activation of inflammatory cells, which increases MMP 8 and MMP 9 and thereby leads to the degradation of collagen and cervical softening. |
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Authors:
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Annette Aronsson; Ann-Kristin Ulfgren; Berit Ståbi; Anneli Stavreus-Evers; Kristina Gemzell-Danielsson |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Contraception Volume: 72 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-20 Completed Date: 2005-11-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
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Languages: eng Pagination: 33-9 Citation Subset: IM |
Affiliation:
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Department of Woman and Child Health, Division for Obstetrics and Gynecology, Karolinska Institute, S-171 76 Stockholm, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage* Abortion, Induced Administration, Intravaginal Administration, Oral Adult Antigens, CD / analysis Antigens, CD45 / analysis Antigens, Differentiation, Myelomonocytic / analysis Cervical Ripening / drug effects* Female Gestational Age* Humans Immunohistochemistry Inflammation* Matrix Metalloproteinase 8 / analysis Matrix Metalloproteinase 9 / analysis Misoprostol / administration & dosage* Pregnancy Tissue Inhibitor of Metalloproteinase-1 / analysis Tissue Inhibitor of Metalloproteinase-2 / analysis Vacuum Curettage |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/Tissue Inhibitor of Metalloproteinase-1; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; 59122-46-2/Misoprostol; EC 3.1.3.48/Antigens, CD45; EC 3.4.24.34/Matrix Metalloproteinase 8; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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