Document Detail

The effect of oral sodium taurocholate on endotoxemia and intestinal anastomotic wound healing in rats with obstructive jaundice.
MedLine Citation:
PMID:  10870583     Owner:  NLM     Status:  MEDLINE    
The effect of sodium taurocholate (ST) on endotoxemia and intestinal anastomotic wound healing in obstructive jaundice was evaluated in a rat model. A total of 108 Wistar rats were divided into three main groups. Thus, 36 animals were given ileal anastomosis (IA) alone (IA group), 36 were given IA with bile duct ligation (BDL) (IA + BDL group), and 36 were given IA with BDL and oral sodium taurocholate (ST) (IA + BDL + ST group). These three main groups were then divided into three equal subgroups, A, B, and C, which were killed on postoperative days (POD) 3, 5, and 9, respectively. In the IA + BDL + ST group, ST was administrated perioperatively and ceased from POD 5 onwards. The anastomotic hydroxyproline level and bursting pressure were significantly lower in the IA + BDL animals compared with the others on POD 3, 5, and 9 (P < 0.008). Endotoxemia was prominent in the IA + BDL group from POD 3 (P = 0.011). After ST was stopped, 42% of the AI + BDL + ST animals developed endotoxemia by POD 9 (P = 0.008). Anastomotic wound healing was better in the IA + BDL + ST group (P < 0.01). These findings suggest that endotoxemia and its adverse effects on wound healing in obstructive jaundice can be prevented by the oral administration of ST.
M Sayan; A Alponat; N Yavuz; E Altinkaya; S Göksel; M Sariyar
Related Documents :
3534863 - Effects of captopril on myocardial perfusion in patients with coronary insufficiency: e...
933353 - The significance of t-loop change in frank's lead exercise electrocardiography.
16896293 - The role of ambulatory mechanics in the initiation and progression of knee osteoarthritis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery today     Volume:  27     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  1997  
Date Detail:
Created Date:  2000-07-17     Completed Date:  2000-07-17     Revised Date:  2006-08-03    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  953-7     Citation Subset:  IM    
Department of Surgery, University of Istanbul, Cerrahpasa Medical School, Aksaray, Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anastomosis, Surgical*
Cholestasis / physiopathology*
Endotoxemia / physiopathology*
Hydroxyproline / metabolism
Ileum / surgery
Intestines / surgery*
Rats, Wistar
Taurocholic Acid / pharmacology*
Wound Healing / drug effects*
Reg. No./Substance:
51-35-4/Hydroxyproline; 81-24-3/Taurocholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The beneficial effects of recombinant human insulin-like growth factor-I (IGF-I) on wound healing in...
Next Document:  Development of black gallstones after the nonsurgical management of splenic injury: report of a case...