| The effect of oral exposure to trioxane on the oestrous cycle in rats. | |
| | |
MedLine Citation:
|
PMID: 2130874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An aqueous solution of trioxane was administered by gavage to female rats, 5 days per week for 7 weeks, at doses of 0.19, 0.58 and 1.16 g/kg/day. A significant increase in the mean duration of the oestrous cycle, mainly due to lengthening of the dioestrus, was only noted in the 6th and 7th week of treatment in females given per os trioxane at a dose of 1.16 g/kg. Three weeks after cessation of treatment, no alterations of oestrous cycle were observed in all groups. Since a dose-related decrease in body weight gain was observed in females given trioxane by gavage at doses of 0.19-1.16 g/kg and trioxane-induced behavioral changes were seen in the 1.16 g/kg group, it was concluded that exposure to trioxane did not affect the sexual cycle unless other overt signs of trioxane toxicity were induced. |
| | |
Authors:
|
K Sitarek; B Barański |
Related Documents
:
|
12724784 - Ntp toxicology and carcinogenesis studies of nitrofurantoin (cas no. 67-20-9) in f344/n... 19265284 - Collaborative work on evaluation of ovarian toxicity. 17) two- or four-week repeated-do... 19783574 - Effects of piperonyl butoxide on spontaneous behavior in f1-generation mice. 23092554 - Effects of low-dose ionizing radiation and menadione, an inducer of oxidative stress, a... 12802384 - Gaseous superoxide potentiation of the effect of nonnarcotic analgesics in low doses. 10666494 - Acute alteration in bone mineral density and biochemical markers for bone metabolism in... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Polish journal of occupational medicine Volume: 3 ISSN: 0860-6536 ISO Abbreviation: Pol J Occup Med Publication Date: 1990 |
Date Detail:
|
Created Date: 1991-12-09 Completed Date: 1991-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9012925 Medline TA: Pol J Occup Med Country: POLAND |
Other Details:
|
Languages: eng Pagination: 209-13 Citation Subset: IM |
Affiliation:
|
Department of Occupational Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Weight Estrus / drug effects* Female Heterocyclic Compounds / toxicity* Mutagens / toxicity* Random Allocation Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
|
0/Heterocyclic Compounds; 0/Mutagens; 110-88-3/s-trioxane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Statistical analysis of the genotoxicity study results.
Next Document: Effects of a single exposure to chlorphenvinphos, an organophosphate insecticide, on hot-plate behav...