Document Detail


The effect of oral cimetidine on total and unbound serum lidocaine concentrations in patients with suspected myocardial infarction.
MedLine Citation:
PMID:  3804509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we prospectively evaluated the effect of oral cimetidine on serum lidocaine concentrations in 6 patients with suspected myocardial infarction. Compared to baseline lidocaine levels, total lidocaine concentrations increased by 8.2 +/- 7.8% at 6 hours, 16.4 +/- 9.0% at 12 hours and 27.9 +/- 9.4% at 24 hours after two doses of oral cimetidine. Unbound lidocaine concentrations increased by 14.3 +/- 4.1% at 6 hours, and 18.3 +/- 10.3% at 24 hours after cimetidine. In patients with myocardial infarction (3), total lidocaine concentrations increased by 24.2 +/- 10.4%, whereas unbound lidocaine increased by 8.9 +/- 10.2% at 24 hours. Therefore, increases in total lidocaine concentrations after cimetidine administration were considerably less than those previously reported and empiric dosage reductions of lidocaine in patients receiving cimetidine may not be appropriate.
Authors:
S I Berk; P Gal; J L Bauman; J B Douglas; J D McCue; J R Powell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  14     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-03-12     Completed Date:  1987-03-12     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  91-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Aged
Cimetidine / pharmacology*
Drug Interactions
Humans
Lidocaine / blood*,  pharmacology
Male
Middle Aged
Myocardial Infarction / blood*
Prospective Studies
Ventricular Fibrillation / prevention & control
Chemical
Reg. No./Substance:
137-58-6/Lidocaine; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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